Comparison of gray matter volume between migraine and "strict-criteria" tension-type headache.
Comparison of gray matter volume between migraine and "strict-criteria" tension-type headache.
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DOI：
10.1186/s10194-018-0834-6
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发表时间：
2018-01-15
期刊：
影响因子：
--
通讯作者：
Wang SJ
中科院分区：
文献类型：
--
作者：
Chen WT;Chou KH;Lee PL;Hsiao FJ;Niddam DM;Lai KL;Fuh JL;Lin CP;Wang SJ
尽管症状明显不同，但紧张型头痛 (TTH) 和偏头痛具有高度共病性，并且在临床实践中表现出许多相似之处。本研究的目的是调查两种类型的头痛在大脑形态上是否相似。连续入组 TTH 患者以及年龄和性别匹配的偏头痛患者以及健康对照者进行脑磁共振成像检查。如果患有 TTH 的患者报告有任何头痛特征或偏头痛的相关症状，则将其排除在外。使用基于体素的形态测量法检查与头痛诊断（TTH 与偏头痛）和频率（发作性与慢性）相关的灰质 (GM) 体积的变化。还研究了这些 GM 变化与头痛特征的相关性以及 TTH 和偏头痛之间的区分能力。与对照组（n = 43）相比，TTH 患者（25 例发作性和 24 例慢性）表现出前扣带皮层、边缘上回、颞极、枕叶皮质和尾状核的 GM 体积增加。相反，偏头痛患者（31 例为发作性偏头痛，25 例为慢性偏头痛）则表现出眶额皮质 GM 体积减少。这些 GM 变化与任何头痛特征均无关。体素方面的 2 × 2 因子分析进一步揭示了头痛类型和频率对 TTH 和偏头痛之间 GM 体积比较的实质性影响。具体来说，偏头痛组（与 TTH 组）的额上回和中回、小脑、背侧纹状体和楔前叶的 GM 均下降。慢性组（相对于发作性组）另外表现出双侧岛叶和前扣带皮层的 GM 降低。在接受者操作特征分析中，左侧额上回和右侧小脑V组合的GM体积对于区分TTH和偏头痛具有良好的判别能力（曲线下面积 = 0.806）。 TTH 和偏头痛是不同的头痛疾病，在 GM 变化方面具有不同的特征。两种类型头痛之间的主要形态差异是偏头痛中前额叶和小脑区域的相对 GM 降低，这可能反映了与这种致残性头痛相关的较高的稳态负荷。本文的在线版本 (10.1186/s10194-018-0834-6) 包含补充材料，可供授权用户使用。
Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both types of headaches are similar in brain morphology. Consecutive patients with TTH and age- and sex-matched patients with migraine and healthy controls were enrolled for brain magnetic resonance imaging examination. Patients with TTH were excluded if they reported any headache features or associated symptoms of migraine. Changes in gray matter (GM) volume associated with headache diagnosis (TTH vs. migraine) and frequency (episodic vs. chronic) were examined using voxel-based morphometry. The correlation with headache profile and the discriminative ability between TTH and migraine were also investigated for these GM changes. In comparison with controls (n = 43), the patients with TTH (25 episodic and 24 chronic) exhibited a GM volume increase in the anterior cingulate cortex, supramarginal gyrus, temporal pole, lateral occipital cortex, and caudate. The patients with migraine (31 episodic and 25 chronic) conversely exhibited a GM volume decrease in the orbitofrontal cortex. These GM changes did not correlate with any headache profile. A voxel-wise 2 × 2 factorial analysis further revealed the substantial effects of headache types and frequency in the comparison of GM volume between TTH and migraine. Specifically, the migraine group (vs. TTH) had a GM decrease in the superior and middle frontal gyri, cerebellum, dorsal striatum, and precuneus. The chronic group (vs. episodic group) otherwise demonstrated a GM decrease in the bilateral insula and anterior cingulate cortex. In receiver operating characteristic analysis, the GM volumes of the left superior frontal gyrus and right cerebellum V combined had good discriminative ability for distinguishing TTH and migraine (area under the curve = 0.806). TTH and migraine are separate headache disorders with different characteristics in relation to GM changes. The major morphological difference between the two types of headaches is the relative GM decrease of the prefrontal and cerebellar regions in migraine, which may reflect a higher allostatic load associated with this disabling headache. The online version of this article (10.1186/s10194-018-0834-6) contains supplementary material, which is available to authorized users.
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DOI：
10.1186/s10194-016-0698-6
发表时间：
2016-12
期刊：
The journal of headache and pain
影响因子：
--
作者：
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