Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis.
Brief Maternal Separation Promotes Resilience to Anxiety-like and Depressive-like Behaviors in Female C57BL/6J Offspring with Imiquimod-Induced Psoriasis.
复制标题
短暂的母体分离促进了患有咪喹莫特诱发银屑病的女性 C57BL/6J 后代对焦虑样和抑郁样行为的恢复能力
DOI：
10.3390/brainsci12091250
复制
发表时间：
2022-09-15
期刊：
影响因子：
3.3
通讯作者：
Wang, Gaohua
中科院分区：
文献类型：
--
作者：
Zhou, Lin;Wu, Zuotian;Li, Yixin;Xiao, Ling;Wang, Huiling;Wang, Gaohua
背景：银屑病是一种常见的慢性炎症性皮肤病，常导致抑郁。早期生活经历会影响大脑发育，并与抑郁症有关。早期生活中不同的MS方案对咪喹莫特(Imiquimod)诱导的银屑病雌性后代的焦虑样和抑郁样行为的影响尚不清楚。方法：C57BL/6J小鼠从产后第1天至第21天分别给予不分离(NMS)、短时MS(15min/d，MS15)和长MS(180min/d，MS180)。成人涂抹5%咪喹莫特乳膏8天。行为测试、皮肤损伤和海马区蛋白表达也进行了评估。结果：使用ImQ后，我们在雌性小鼠身上发现了明显的银屑病样皮肤病变，小鼠表现出焦虑和抑郁的行为。此外，在应用ImQ后，小鼠的小胶质细胞活化增加，神经可塑性的表达减少。然而，在生命早期的MS15之后，小鼠表现出类似焦虑和抑郁的行为减少，这表明了弹性。此外，还检测到抑制海马神经炎症和增加神经可塑性。结论：总体而言，本研究证实了简明多发性硬化症对ImQ诱导的银屑病雌性子代的行为缺陷具有韧性，并逆转了神经炎症的激活和神经可塑性损伤的损害。
Background: Psoriasis is a common chronic inflammatory skin disease that often causes depression. Early life experience affects brain development and relates to depression. Whether the effect of different MS protocols in early life on anxiety-like and depressive-like behaviors in female offspring with imiquimod (IMQ)-induced psoriasis is unknown. Methods: C57BL/6J mice were subjected to no separation (NMS), brief MS (15 min/day, MS15) or long MS (180 min/day, MS180) from postpartum days (PPD) 1 to PPD21. Then, 5% imiquimod cream was applied for 8 days in adults. Behavioral tests, skin lesions and hippocampal protein expression were also assessed. Results: We found significant psoriasis-like skin lesions in female mice following IMQ application, and mice showed anxiety-like and depressive-like behaviors. Further, increased microglial activation and decreased expression of neuroplasticity were detected in mice following IMQ application. However, after MS15 in early life, mice showed decreased anxiety-like and depressive-like behaviors, indicating resilience. Further, inhibited hippocampal neuroinflammation and increased neuroplasticity were detected. Conclusions: Collectively, this study confirms that brief MS confers resilience to the behavior deficits in female offspring with IMQ-induced psoriasis and reverses the activation of neuroinflammation and the damage of neuroplasticity injury.
登录
查看更多内容
早期生活节目和神经发育障碍。
影响因子：
10.6
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
通讯作者：
Nestler, Eric J.
神经可塑性在抑郁症中的作用：从海马到前额皮质
影响因子：
3.1
作者：
Liu W;Ge T;Leng Y;Pan Z;Fan J;Yang W;Cui R
通讯作者：
Cui R
影响因子：
16.2
作者：
Largo-Barrientos P;Apóstolo N;Creemers E;Callaerts-Vegh Z;Swerts J;Davies C;McInnes J;Wierda K;De Strooper B;Spires-Jones T;de Wit J;Uytterhoeven V;Verstreken P
通讯作者：
Verstreken P
影响因子：
15.1
作者：
Delpech, Jean-Christophe;Wei, Lan;Hao, Jin;Yu, Xiaoqing;Madore, Charlotte;Butovsky, Oleg;Kaffman, Arie
通讯作者：
Kaffman, Arie
DOI：
10.1002/advs.202104106
发表时间：
2022-05
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
通讯作者：
--