Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities.
Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities.
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DOI：
10.1186/1471-2105-11-260
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发表时间：
2010-05-18
影响因子：
3
通讯作者：
Shamu CE
中科院分区：
文献类型：
--
作者：
Tolopko AN;Sullivan JP;Erickson SD;Wrobel D;Chiang SL;Rudnicki K;Rudnicki S;Nale J;Selfors LM;Greenhouse D;Muhlich JL;Shamu CE
共享使用的高通量筛选（HTS）设施在生物医学中变得越来越普遍，因为大规模的小分子和基因组规模的RNAi筛选策略被用于基础研究目的。这些共享设施需要一个独特的信息学基础设施，不仅必须提供对筛查数据的访问和分析，而且还必须管理与多个独立研究小组进行的大量交叉筛查工作相关的行政和技术挑战。我们已经开发了Screensaver，一个免费的，开源的，基于Web的实验室信息管理系统（LIMS），以满足我们的小分子和RNAi筛选设施的信息学需求。屏幕保护程序支持筛选数据集的存储和比较，以及有关屏幕、筛选器、库和实验室工作请求的信息的管理。据我们所知，Screensaver是首批支持存储和分析基因组规模RNAi筛选项目和小分子筛选项目数据的应用程序之一。HTS设施的信息学和管理需求最好由单个、集成、可通过网络访问的应用程序（如屏幕保护程序）管理。屏幕保护程序已被证明在满足哈佛医学院ICCB-朗伍德/NSRB筛查设施的要求方面很有用，并为其他HTS设施提供了类似的好处。
Shared-usage high throughput screening (HTS) facilities are becoming more common in academe as large-scale small molecule and genome-scale RNAi screening strategies are adopted for basic research purposes. These shared facilities require a unique informatics infrastructure that must not only provide access to and analysis of screening data, but must also manage the administrative and technical challenges associated with conducting numerous, interleaved screening efforts run by multiple independent research groups. We have developed Screensaver, a free, open source, web-based lab information management system (LIMS), to address the informatics needs of our small molecule and RNAi screening facility. Screensaver supports the storage and comparison of screening data sets, as well as the management of information about screens, screeners, libraries, and laboratory work requests. To our knowledge, Screensaver is one of the first applications to support the storage and analysis of data from both genome-scale RNAi screening projects and small molecule screening projects. The informatics and administrative needs of an HTS facility may be best managed by a single, integrated, web-accessible application such as Screensaver. Screensaver has proven useful in meeting the requirements of the ICCB-Longwood/NSRB Screening Facility at Harvard Medical School, and has provided similar benefits to other HTS facilities.
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影响因子：
14.9
作者：
Gilsdorf, Moritz;Horn, Thomas;Boutros, Michael
通讯作者：
Boutros, Michael
影响因子：
46.9
作者：
Taylor, Chris F.;Field, Dawn;Sansone, Susanna-Assunta;Aerts, Jan;Apweiler, Rolf;Ashburner, Michael;Ball, Catherine A.;Binz, Pierre-Alain;Bogue, Molly;Booth, Tim;Brazma, Alvis;Brinkman, Ryan R.;Clark, Adam Michael;Deutsch, Eric W.;Fiehn, Oliver;Fostel, Jennifer;Ghazal, Peter;Gibson, Frank;Gray, Tanya;Grimes, Graeme;Hancock, John M.;Hardy, Nigel W.;Hermjakob, Henning;Julian, Randall K., Jr.;Kane, Matthew;Kettner, Carsten;Kinsinger, Christopher;Kolker, Eugene;Kuiper, Martin;Le Novere, Nicolas;Leebens-Mack, Jim;Lewis, Suzanna E.;Lord, Phillip;Mallon, Ann-Marie;Marthandan, Nishanth;Masuya, Hiroshi;McNally, Ruth;Mehrle, Alexander;Morrison, Norman;Orchard, Sandra;Quackenbush, John;Reecy, James M.;Robertson, Donald G.;Rocca-Serra, Philippe;Rodriguez, Henry;Rosenfelder, Heiko;Santoyo-Lopez, Javier;Scheuermann, Richard H.;Schober, Daniel;Smith, Barry;Snape, Jason;Stoeckert, Christian J., Jr.;Tipton, Keith;Sterk, Peter;Untergasser, Andreas;Vandesompele, Jo;Wiemann, Stefan
通讯作者：
Wiemann, Stefan
影响因子：
14.9
作者：
Maglott, Donna;Ostell, Jim;Pruitt, Kim D;Tatusova, Tatiana
通讯作者：
Tatusova, Tatiana
DOI：
10.1021/ci00057a005
发表时间：
1988-02-01
期刊：
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
影响因子：
--
作者：
WEININGER, D
通讯作者：
WEININGER, D
影响因子：
14.9
作者：
Flockhart, Ian;Booker, Matthew;Mathey-Prevot, Bernard
通讯作者：
Mathey-Prevot, Bernard