Optical coherence tomography imaging during thyroid and parathyroid surgery: a novel system of tissue identification and differentiation to obviate tissue resection and frozen section.
Optical coherence tomography imaging during thyroid and parathyroid surgery: a novel system of tissue identification and differentiation to obviate tissue resection and frozen section.
复制标题
甲状腺和甲状旁腺手术期间的光学相干断层扫描成像：一种新型的组织鉴定和分化系统，以消除组织切除和冷冻截面。
DOI：
10.1002/hed.23452
复制
发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Randolph GW
中科院分区：
文献类型：
--
作者：
Conti de Freitas LC;Phelan E;Liu L;Gardecki J;Namati E;Warger WC;Tearney GJ;Randolph GW
光学相干断层扫描（OCT）允许组织组织学样评价，但没有组织固定或染色。我们研究了在甲状腺和甲状旁腺手术中获得的组织的OCT图像，以初步评估这些图像是否包含足够的信息用于识别和区分正常颈部组织。正常组织取自接受手术治疗的患者。两个新一代OCT系统，包括光学频域成像（OFDI）和μOCT，进行了比较，代表性的苏木精-伊红组织学。评价甲状腺、脂肪、肌肉、淋巴结和甲状旁腺组织。使用两种系统对所有检查的组织类型实现了足以用于组织类型识别的组织学样显微特征。这项初步研究表明，新一代OCT系统能够识别和区分甲状腺和甲状旁腺手术中遇到的颈部组织。OCT小型化和无菌术中探头形式的发展的进一步进步可能允许OCT提供术中“光学活检”，而无需固定、染色或组织切除。
Optical coherence tomography (OCT) allows tissue histologic-like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroid surgeries to provide a preliminary assessment as to whether these images contain sufficient information for recognition and differentiation of normal neck tissues. Normal tissues were obtained from patients undergoing surgical treatment. Two new-generation OCT systems, including optical frequency domain imaging (OFDI) and μOCT, were compared to representative hematoxylin-eosin histology. Thyroid, fat, muscle, lymph nodes, and parathyroid tissues were evaluated. Histologic-like microscopic characteristics sufficient for tissue type identification was realized using both systems for all tissue types examined. This pilot study demonstrated that new-generation OCT systems are capable of recognizing and differentiating neck tissues encountered during thyroid and parathyroid surgeries. Further advances in OCT miniaturization and development of sterile intraoperative probe formats may allow OCT to offer an intraoperative “optical biopsy” without fixation, staining, or tissue resection.
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DOI：
10.4244/eijv4i5a105
发表时间：
2009-03
期刊：
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
影响因子：
--
作者：
Low AF;Kawase Y;Chan YH;Tearney GJ;Bouma BE;Jang IK
通讯作者：
Jang IK
影响因子：
3.6
作者：
Golubovic, B;Bouma, BE;Fujimoto, JG
通讯作者：
Fujimoto, JG
影响因子：
1.3
作者：
Cibas, Edmund S.;Alexander, Erik K.;Mandel, Susan J.
通讯作者：
Mandel, Susan J.
影响因子：
3.4
作者：
Cavicchi, Ottavio;Piccin, Ottavio;Ceroni, Alberto Rinaldi
通讯作者：
Ceroni, Alberto Rinaldi
影响因子：
2.6
作者：
Hwang, Harry S.;Perez, Daniel A.;Orloff, Lisa A.
通讯作者：
Orloff, Lisa A.