In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography.
In vivo characterisation of coronary plaques with conventional grey-scale intravascular ultrasound: correlation with optical coherence tomography.
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DOI：
10.4244/eijv4i5a105
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Jang IK
中科院分区：
文献类型：
--
作者：
Low AF;Kawase Y;Chan YH;Tearney GJ;Bouma BE;Jang IK
虽然血管内超声（IVUS）被广泛使用，但关于其在体内定义斑块特征的准确性的已发表数据有限。光学相干断层扫描（OCT）是一种高分辨率成像技术，它利用了正常血管和病变血管成分之间明显的光学对比度。本研究的目的是评价常规灰阶IVUS在识别体内冠状动脉斑块特征，特别是脂质含量作为易损斑块的标志物时，与OCT相比的能力。在接受心脏导管插入术的患者中，进行IVUS和OCT成像。使用两种方式在相应部位对富脂斑块、钙化斑块和斑块破裂进行详细的定性分析。共有146个匹配的研究中心可用于分析。与OCT相比，IVUS识别脂质池的灵敏度较低（24.1%），但特异性较高（93.9%）。IVUS诊断钙化斑块和斑块破裂的敏感性和特异性分别为92.9%、66.4%和66.7%、96.1%。传统的灰阶血管内超声可能不是一种可靠的成像方式，用于检测富含脂质的斑块，因此是易损斑块。这对使用常规灰度IVUS识别易损斑块具有重要意义。
Although intravascular ultrasound (IVUS) is widely used, there is limited published data on its accuracy in defining plaque characteristics in vivo. Optical coherence tomography (OCT) is a high-resolution imaging technique that takes advantage of the pronounced optical contrast between the components of normal and diseased vessels. The aim of this study was to evaluate the ability of conventional grey-scale IVUS in identifying in vivo coronary plaque characteristics, in particular lipid content as a marker of the vulnerable plaque, when compared to OCT. In patients undergoing cardiac catheterisation, IVUS and OCT imaging was performed. Detailed qualitative analysis of lipid-rich plaque, calcific plaque, and plaque disruption were performed at corresponding sites using both modalities. A total of 146 matched sites were available for analysis. When compared to OCT, sensitivity of IVUS for identification of lipid pools was low (24.1%) but specificity was high (93.9%). The sensitivity and specificity of IVUS for detection of calcific plaque and plaque disruption were respectively 92.9%; 66.4%, and 66.7%; 96.1%. Conventional grey-scale IVUS may not be a reliable imaging modality for detection of lipid-rich and hence vulnerable plaques. This has important implications in using conventional grey-scale IVUS to identify the vulnerable plaque.
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影响因子：
3.8
作者：
Yun, SH;Tearney, GJ;de Boer, JF
通讯作者：
de Boer, JF
DOI：
10.1016/s0735-1097(01)01175-5
发表时间：
2001-04-01
影响因子：
24
作者：
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作者：
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作者：
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通讯作者：
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影响因子：
39.3
作者：
Palmer, ND;Northridge, D;Fox, KAA
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Fox, KAA