Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies.
Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies.
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DOI：
10.3390/ijms18112270
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发表时间：
2017-10-28
影响因子：
5.6
通讯作者：
Chen YH
中科院分区：
文献类型：
--
作者：
Chavez LM;Huang SS;MacDonald I;Lin JG;Lee YC;Chen YH
针灸是世界卫生组织(WHO)推荐的中风治疗和改善中风护理的替代和补充策略。临床试验和荟萃分析结果表明，针灸在改善中风后平衡功能、减少痉挛、增加肌肉力量和总体幸福感方面具有疗效。针灸在中风康复中的有益效果背后的机制尚不清楚。本研究的目的是进行文献综述，总结目前已知的针灸和电针治疗在缺血性中风康复中的作用机制，并详细介绍与这些效应有关的常用穴位。本综述中的证据表明，针刺/电针对缺血性卒中康复的有益作用涉及五个不同的机制：(1)促进中枢神经系统(CNS)的神经发生和细胞增殖；(2)调节缺血区的脑血流；(3)抗缺血区的细胞凋亡；(4)调节神经化学物质；(5)改善卒中后受损的长时程增强(LTP)和记忆。基础研究中常用的穴位有百会穴、足三里穴、曲池穴、水沟穴、大椎穴和合谷穴。我们的研究结果表明，针刺对缺血性中风的治疗是通过调节中枢神经系统的不同机制发挥有益作用的。
Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.
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