Obesity survival paradox in pneumonia: a meta-analysis.
Obesity survival paradox in pneumonia: a meta-analysis.
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DOI：
10.1186/1741-7015-12-61
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发表时间：
2014-04-10
期刊：
影响因子：
9.3
通讯作者：
Xiu Q
中科院分区：
文献类型：
--
作者：
Nie W;Zhang Y;Jee SH;Jung KJ;Li B;Xiu Q
目前还不清楚肺炎是否存在“肥胖生存悖论”。因此，我们进行了一项荟萃分析，以评估体重指数（BMI）增加，肺炎风险和死亡风险之间的关联。从PubMed和Embase数据库中识别队列研究。使用随机效应模型计算总结相对风险（RR）及其相应的95%置信区间（CI）。纳入了13项肺炎风险队列研究（n = 1，536，623）和10项死亡率队列研究（n = 1，375，482）。超重和肥胖个体与肺炎风险增加显著相关（RR = 1.33，95%CI 1.04 - 1.71，P = 0.02，I2 = 87%）。在剂量反应分析中，BMI每增加5 kg/m2，肺炎的估计汇总RR为1.04（95%CI 1.01至1.07，P = 0.01，I2 = 84%）。超重、肥胖和体弱者与肺炎死亡风险降低显著相关（RR = 0.83，95% CI 0.77 ~ 0.91，P < 0.01，I2 = 34%）。BMI每增加5 kg/m2死亡率的估计汇总RR为0.95（95% CI 0.93 - 0.98，P < 0.01，I2 = 77%）。这项荟萃分析表明，肺炎存在“肥胖生存悖论”。由于这项荟萃分析是基于观察性研究，因此需要更多的研究来证实结果。
It is unclear whether an ‘obesity survival paradox’ exists for pneumonia. Therefore, we conducted a meta-analysis to assess the associations between increased body mass index (BMI), pneumonia risk, and mortality risk. Cohort studies were identified from the PubMed and Embase databases. Summary relative risks (RRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random effects model. Thirteen cohort studies on pneumonia risk (n = 1,536,623), and ten cohort studies on mortality (n = 1,375,482) were included. Overweight and obese individuals were significantly associated with an increased risk of pneumonia (RR = 1.33, 95% CI 1.04 to 1.71, P = 0.02, I2 = 87%). In the dose–response analysis, the estimated summary RR of pneumonia per 5 kg/m2 increase in BMI was 1.04 (95% CI 1.01 to 1.07, P = 0.01, I2 = 84%). Inversely, overweight and obese subjects were significantly associated with reduced risk of pneumonia mortality (RR = 0.83, 95% CI 0.77 to 0.91, P < 0.01, I2 = 34%). The estimated summary RR of mortality per 5 kg/m2 increase in BMI was 0.95 (95% CI 0.93 to 0.98, P < 0.01, I2 = 77%). This meta-analysis suggests that an ‘obesity survival paradox’ exists for pneumonia. Because this meta-analysis is based on observational studies, more studies are required to confirm the results.
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DOI：
10.1183/09031936.00185211
发表时间：
2013-04
期刊：
The European respiratory journal
影响因子：
--
作者：
King P;Mortensen EM;Bollinger M;Restrepo MI;Copeland LA;Pugh MJ;Nakashima B;Anzueto A;Hitchcock Noël P
通讯作者：
Hitchcock Noël P
影响因子：
4.4
作者：
Blumentals WA;Nevitt A;Peng MM;Toovey S
通讯作者：
Toovey S
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
--
作者：
Baik, I;Curhan, GC;Fawzi, WW
通讯作者：
Fawzi, WW
影响因子：
6.3
作者：
Aregbesola, Alex;Voutilainen, Sari;Tuomainen, Tomi-Pekka
通讯作者：
Tuomainen, Tomi-Pekka