Plasma Omentin-1 Level as a Predictor of Good Coronary Collateral Circulation.
Plasma Omentin-1 Level as a Predictor of Good Coronary Collateral Circulation.
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血浆 Omentin-1 水平作为良好冠状动脉侧支循环的预测因子。
DOI：
10.5551/jat.37440
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发表时间：
2017-09-01
影响因子：
4.4
通讯作者：
Zhang GG
中科院分区：
文献类型：
--
作者：
Zhou JP;Tong XY;Zhu LP;Luo JM;Luo Y;Bai YP;Li CC;Zhang GG
目的：冠状动脉侧支循环(CCC)在急性脑缺血发作中起着至关重要的作用。有证据表明，omentin-1具有显著的抗动脉粥样硬化和缺血诱导的血管重建作用。本研究的目的是探讨≥冠状动脉造影证实的90%冠脉闭塞患者血浆omentin-1水平与冠状动脉闭塞的关系。方法：入选14 2例≥患者，其中至少1支主要心外膜冠状动脉有90%的管腔狭窄。其中Rtrop评分0~1级的79例为CCC差组，Rtrop 2~3级的63例为CCC良好组。评估血浆omentin-1水平与CCC状态之间的关系。结果：正常组血浆omentin-1水平显著高于不良组(566.57±26.90vs.492.38±19.70 ng/mL，P=0.024)。此外，omentin-1与总胆固醇(TC)、高密度脂蛋白、Gensini评分呈正相关，与高脂血症、体重指数呈负相关(P均<0.05)。多因素回归分析显示，omentin-1[优势比(OR)=1.002，95%可信区间(CI)：1.000~1.004，p=0.041]、TC、病变血管数、左回旋支和右冠状动脉高频率、慢性完全闭塞和Gensini评分仍是良好的预后因素。结论：血浆omentin-1水平越高，CCC发生越好。我们的研究结果表明，在≥冠状动脉闭塞90%的患者中，omentin-1可能是合适的ccp的替代标记物。
Aims: Coronary collateral circulation (CCC) is crucial during an acute ischemic attack. Evidences showed that omentin-1 exhibited remarkable antiatherogenic effects and ischemia-induced revascularization. The aim of this study was to investigate the relationship between plasma omentin-1 levels and CCC in patients with ≥ 90% angiography-proven coronary occlusion. Methods: 142 patients with ≥ 90% luminal diameter stenosis in at least one major epicardial coronary artery were recruited. Among them, 79 patients with Rentrop 0–1 grade were classified into the poor CCC group and 63 patients with Rentrop 2–3 grade were included into the good CCC group. The association between plasma omentin-1 levels and CCC status was assessed. Results: Plasma omentin-1 level was significantly higher in patients with good CCC than those with poor CCC (566.57 ± 26.90 vs. 492.38 ± 19.70 ng/mL, p = 0.024). Besides, omentin-1 was positively correlated with total cholesterol (TC), high-density lipoprotein, and gensini score but inversely with hyperlipidemia and body mass index (all p values < 0.05). Multivariate regression analysis indicated that omentin-1 [odds ratio (OR) = 1.002, 95% confidence interval (CI): 1.000 – 1.004, p = 0.041)], TC, the number of the diseased vessels, a higher frequency of left circumflex artery and right coronary artery, chronic total occlusion, and gensini score remained as the independent predictors of good CCC. Conclusion: Higher plasma omentin-1 level was associated with better CCC development. Our findings suggest that omentin-1 may be an alternative marker for adequate CCC in patients with ≥ 90% coronary occlusion.
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影响因子：
2.6
作者：
Shang, Fu-Jun;Wang, Jie-Pin;Zhao, Lian-You
通讯作者：
Zhao, Lian-You
影响因子：
3.3
作者：
Ege, Meltem Refiker;Acikgoz, Savas;Kisacik, Halil
通讯作者：
Kisacik, Halil
DOI：
10.1016/j.bbaexp.2005.11.005
发表时间：
2005-12-30
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Schäffler, A;Neumeier, A;Büchler, C
通讯作者：
Büchler, C
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
7.5
作者：
Fan, Ying;Li, Sha;Li, Jian-Jun
通讯作者：
Li, Jian-Jun