There may be two tumor suppressor genes on chromosome arm Ip closely associated with biologically distinct subtypes of neuroblastoma
There may be two tumor suppressor genes on chromosome arm Ip closely associated with biologically distinct subtypes of neuroblastoma
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染色体臂 Ip 上可能有两个肿瘤抑制基因与神经母细胞瘤生物学上不同的亚型密切相关
作者：
O. Takeda;C. Homma;N. Maseki;M. Sakurai;N. Kanda;M. Schwab;Y. Nakamura;Y. Kaneko
我们使用 14 个多态性 DNA 标记研究了 108 个神经母细胞瘤中染色体臂 Ip 杂合性丢失 (LOH)。一百零四个具有一个或多个信息基因座的肿瘤； 104 个肿瘤中的 21 个 (20%) 在 Ip 上显示 LOH，并根据间质或末端等位基因丢失以及 Ip 上是否存在 LOH 分为三组。 21个肿瘤中的7个显示出包含Ip36中的小区域的间质缺失（A组），另外14个显示出包含从Ipter到Ip32的区域的末端缺失（B组）。 83 个 I p 上无 LOH 的肿瘤被归类为 C 组。A 组患者大多小于 12 个月大 (6/7)，经常被婴儿大规模筛查计划发现 (5/7)，患有非肾上腺起源的肿瘤，很少进展到 IV 期 (1/7)。大多数 B 组患者年龄为 12 个月或以上 (11/14)，在临床上发现 (11/14)，患有肾上腺来源的肿瘤，并进展至 IV 期 (10/14)。 C组肿瘤的生物学特征分析表明它们可能包含A组和B组肿瘤。虽然所有 A 组肿瘤均处于三倍体范围 (3n) (4/4)，但大多数 B 组肿瘤为二倍体 (2n) 或四倍体 (4n) (7/10)。在 8 个 B 组肿瘤中发现了 MYCN 扩增，但在 A 组肿瘤中没有发现。 A、B 和 C 组患者的 3 年无事件生存率分别为 86%、49% 和 74%（P = 0.0287）。这些发现表明，Ip 上可能存在两个肿瘤抑制基因，它们与两种生物学上不同的神经母细胞瘤亚型密切相关。基因铬癌 10:30–39 (1994)。 © 1994 Wiley-Liss, Inc.
We studied loss of heterozygosity (LOH) on chromosome arm Ip in 108 neuroblastomas using 14 polymorphic DNA markers. One‐hundred and four tumors with one or more informative loci; 21 (20%) of the 104 tumors showed LOH on Ip, and were classified into three groups on the basis of interstitial or terminal allelic loss, and presence or absence of LOH on Ip. Seven of the 21 tumors showed an interstitial deletion which encompassed a small region in Ip36 (group A), and the other 14 showed a terminal deletion which encompassed the region from I pter to Ip32 (group B). Eighty‐three tumors without LOH on I p were classified as group C. The group A patients were mostly less than 12 months of age (6/7), were frequently found by a mass screening program for infants (5/7), had a tumor of non‐adrenal origin, and rarely progressed to stage IV (1/7). Most group B patients were 12 months or older (11/14), were found clinically (11/14), had tumors of adrenal origin, and progressed to stage IV (10/14). Analysis of biologic characteristics in group C tumors suggested that they may comprise group A and B tumors. While all group A tumors were in the triploid range (3n) (4/4), most group B tumors were diploid (2n) or tetraploid (4n) (7/10). MYCN amplification was found in 8 group B tumors, but in none of group A tumors. Event‐free survivals of groups A, B, and C patients at 3 years were 86, 49, and 74%, respectively (P = 0.0287). These findings suggest that there may be two tumor suppressor genes on Ip which are closely associated with two biologically distinct subtypes of neuroblastoma. Genes Chrom Cancer 10:30–39 (1994). © 1994 Wiley‐Liss, Inc.
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影响因子：
158.5
作者：
SEEGER, RC;BRODEUR, GM;HAMMOND, D
通讯作者：
HAMMOND, D
影响因子：
158.5
作者：
NAKAGAWARA, A;ARIMANAKAGAWARA, M;BRODEUR, GM
通讯作者：
BRODEUR, GM
影响因子：
56.9
作者：
BRODEUR, GM;SEEGER, RC;BISHOP, JM
通讯作者：
BISHOP, JM
1 号或 14 号染色体杂合性缺失定义了晚期神经母细胞瘤的亚型。
影响因子：
11.2
作者：
Fong,CT;White,PS;Peterson,K;Sapienza,C;Cavenee,WK;Kern,SE;Vogelstein,B;Cantor,AB;Look,AT;Brodeur,GM
通讯作者：
Brodeur,GM
人类神经母细胞瘤以及 1 号和 17 号染色体异常。
影响因子：
11.2
作者：
Gilbert,F;Feder,M;Balaban,G;Brangman,D;Lurie,DK;Podolsky,R;Rinaldt,V;Vinikoor,N;Weisband,J
通讯作者：
Weisband,J