Noradrenergic Signaling in Astrocytes Influences Mammalian Sleep Homeostasis.
Noradrenergic Signaling in Astrocytes Influences Mammalian Sleep Homeostasis.
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DOI：
10.3390/clockssleep4030028
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发表时间：
2022-07-07
期刊：
影响因子：
3.1
通讯作者：
Frank, Marcos G.
中科院分区：
文献类型：
--
作者：
Ingiosi, Ashley M.;Frank, Marcos G.
星形胶质细胞影响睡眠的表达和调节，但参与这些过程的细胞信号通路尚未明确。我们提出星形胶质细胞检测并整合在清醒期间积累的神经元信号，从而导致睡眠驱动增加。去甲肾上腺素（NA）满足星形胶质细胞整合的清醒信号的几个标准。因此，我们研究了NA信号在哺乳动物睡眠中星形胶质细胞中的作用。我们选择性地敲除小鼠星形胶质细胞中的β2-肾上腺素能受体（β2-AR），并在基线条件下和睡眠剥夺（SDep）下记录脑电图和肌电活动。星形胶质β2- ar的cKO增加了基线条件下的活跃期睡眠持续时间，减少了睡眠巩固和非快速眼动慢波活动（SWA）的稳态代偿变化。总的来说，星形胶质NA β2- ar以与我们提出的神经元-星形胶质相互作用模型一致的方式影响哺乳动物睡眠稳态。
Astrocytes influence sleep expression and regulation, but the cellular signaling pathways involved in these processes are poorly defined. We proposed that astrocytes detect and integrate a neuronal signal that accumulates during wakefulness, thereby leading to increased sleep drive. Noradrenaline (NA) satisfies several criteria for a waking signal integrated by astrocytes. We therefore investigated the role of NA signaling in astrocytes in mammalian sleep. We conditionally knocked out (cKO) β2-adrenergic receptors (β2-AR) selectively in astrocytes in mice and recorded electroencephalographic and electromyographic activity under baseline conditions and in response to sleep deprivation (SDep). cKO of astroglial β2-ARs increased active phase siesta duration under baseline conditions and reduced homeostatic compensatory changes in sleep consolidation and non-rapid eye movement slow-wave activity (SWA) after SDep. Overall, astroglial NA β2-ARs influence mammalian sleep homeostasis in a manner consistent with our proposed model of neuronal–astroglial interactions.
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影响因子：
25
作者：
Eban-Rothschild A;Rothschild G;Giardino WJ;Jones JR;de Lecea L
通讯作者：
de Lecea L
影响因子：
2.5
作者：
FRANKEN, P;TOBLER, I;BORBELY, AA
通讯作者：
BORBELY, AA
影响因子：
2.7
作者：
da Costa Daniele, Thiago Medeiros;Carvalhedo de Bruin, Pedro Felipe;Sales de Bruin, Veralice Meireles
通讯作者：
Sales de Bruin, Veralice Meireles
DOI：
10.1016/j.cub.2020.10.012
发表时间：
2021-01-11
期刊：
Current biology : CB
影响因子：
--
作者：
Blum ID;Keleş MF;Baz ES;Han E;Park K;Luu S;Issa H;Brown M;Ho MCW;Tabuchi M;Liu S;Wu MN
通讯作者：
Wu MN
影响因子：
3.5
作者：
Franco, C.;Genis, L.;Torres Aleman, I.
通讯作者：
Torres Aleman, I.