Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV.
Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV.
复制标题
围产期感染艾滋病毒的年轻人体内脂肪和代谢并发症的纵向变化。
DOI：
10.1111/hiv.13566
复制
发表时间：
2024
期刊：
影响因子：
3
通讯作者：
PediatricHIV/AIDSCohortStudy(PHACS)
中科院分区：
文献类型：
--
作者：
Dirajlal-Fargo,Sahera;Jacobson,DeniseL;Yu,Wendy;Mirza,Ayesha;Geffner,MitchellE;Mccomsey,GraceA;Jao,Jennifer;PediatricHIV/AIDSCohortStudy(PHACS)
背景体脂在围产期获得性艾滋病毒（YPHIV）年轻感染者代谢并发症中的作用仍然知之甚少。我们的目的是评估2年内肥胖变化与YPHIV代谢结局的关系。方法PHACS青少年主方案（AMP）研究纳入了2007年至2009年美国15个地点的YPHIV，包括波多黎各。我们纳入了7-19岁的YPHIV患者，他们在基线和2年后通过全身双能X射线吸收仪（DXA）评估了身体成分数据。代谢结果包括胰岛素抵抗（HOMA‐IR）和非高密度脂蛋白胆固醇（non‐HDL‐C）的稳态模型评估。我们拟合线性回归模型来评估2年内体脂增加与第2年和第3年代谢结果的关系。结果所有232名参与者在第2年进行了第二次DXA和HOMA - IR或non - HDL - C测量。首次DXA患者的特征为：年龄12岁（9-14岁）[中位数（Q1-Q3）]，黑人69%，中位数CD4计数714个细胞/μL；70%的HIV RNA <400拷贝/mL。在调整后的分析中，从基线到第2年，体脂每增加1%，HOMA‐IR在第3年增加1.03倍（95% CI: 1.00, 1.05）。我们观察到，从基线到第2年，体脂每增加1%，非HDL - C在第2年增加0.72 mg/dL (95% CI: - 0.04-1.49)，在第3年增加0.81 mg/dL （95% CI: - 0.05-1.66）。结论随着时间的推移，肥胖的增加可能导致下游胰岛素敏感性降低和血脂异常。
BackgroundThe role of body fat on metabolic complications remains poorly understood in young people living with perinatally acquired HIV (YPHIV).ObjectiveOur objective was to assess the association of changes in adiposity over 2 years with metabolic outcomes in YPHIV.MethodsThe PHACS Adolescent Master Protocol (AMP) study enrolled YPHIV from 2007 to 2009 across 15 US sites, including Puerto Rico. We included YPHIV aged 7–19 years with body composition data assessed by whole‐body dual‐energy X‐ray absorptiometry (DXA) at baseline and 2 years later. Metabolic outcomes included homeostatic model assessment of insulin resistance (HOMA‐IR) and non‐high‐density lipoprotein cholesterol (non‐HDL‐C). We fitted linear regression models to assess the association of increase in body fat over 2 years with metabolic outcomes at years 2 and 3.ResultsIn all, 232 participants had a second DXA and either HOMA‐IR or non‐HDL‐C measured at year 2. Participant characteristics at the first DXA were: age 12 years (9–14) [median (Q1–Q3)], 69% Black, and median CD4 count 714 cells/μL; 70% with HIV RNA <400 copies/mL. In adjusted analyses for every 1% increase in body fat from baseline to year 2, HOMA‐IR was higher by 1.03‐fold at year 3 (95% CI: 1.00, 1.05). We observed that for every 1% increase in body fat from baseline to year 2, non‐HDL‐C was 0.72 mg/dL higher at year 2 (95% CI: −0.04–1.49) and 0.81 mg/dL higher at year 3 (95% CI: −0.05–1.66).ConclusionsIncreases in adiposity over time may lead to downstream decreased insulin sensitivity and dyslipidaemia in YPHIV.
影响因子：
5.8
作者：
Hwang, You-Cheol;Fujimoto, Wilfred Y.;Boyko, Edward J.
通讯作者：
Boyko, Edward J.
影响因子：
7.7
作者：
Srinivasan, SR;Myers, L;Berenson, GS
通讯作者：
Berenson, GS
与 HIV-1 感染和联合抗逆转录病毒治疗相关的脂肪重新分布综合征。
影响因子：
2.2
作者：
P. Domingo;V. Estrada;J. López;Francesc Villaroya;E. Martinez
通讯作者：
E. Martinez