Thalamic shape and connectivity abnormalities in children with attention-deficit/hyperactivity disorder.
Thalamic shape and connectivity abnormalities in children with attention-deficit/hyperactivity disorder.
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DOI：
10.1016/j.pscychresns.2012.04.011
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发表时间：
2012-11-30
影响因子：
11.3
通讯作者：
Branch C
中科院分区：
文献类型：
--
作者：
Xia S;Li X;Kimball AE;Kelly MS;Lesser I;Branch C
注意力缺陷多动障碍（ADHD）的特征是皮质-纹状体-丘脑-皮质（CSTC）环路中广泛的结构和功能异常，这些异常有助于注意力和执行功能。在这项研究中，我们分析了丘脑的形状和它的白色物质连接使用结构MRI和扩散张量成像（DTI）的数据从儿童多动症（n=19）和对照组（n=19）。使用基于形状的分析来评估丘脑的形状形态，而使用概率扩散纤维束成像来确定丘脑与其他脑区域之间的连接。基于形状的分析表明，与对照组相比，ADHD儿童的左丘脑区域萎缩显著。对白色物质连通性测量的组分析显示，与对照组相比，ADHD儿童的平均各向异性分数（FA）和丘脑与纹状体、海马和前额叶之间的束的体积显著降低。本研究结果表明，丘脑内的结构异常以及丘脑与其他脑区之间的白色物质轨迹的完整性降低，可能是ADHD注意和执行功能域认知表现受损的解剖学基础。
Attention-deficit/hyperactivity disorder (ADHD) is characterized by widespread structural and functional abnormalities in the cortico-striato-thalmo-cortical (CSTC) loops that subserve attention and executive functions. In this study, we analyzed thalamic shape and its white matter connections using structural MRI and diffusion tensor imaging (DTI) data acquired from children with ADHD (n=19) and controls (n=19). Shape morphology of the thalamus was assessed using shape-based analysis, while connectivity between the thalamus and other brain regions was determined using probabilistic diffusion tractography. Shape-based analysis indicated significant regional atrophy in the left thalamus in children with ADHD compared to controls. Group analyses of white matter connectivity measures showed significantly decreased mean fractional anisotropy (FA) and volume of the tracts between thalamus and striatum, hippocampus, and prefrontal lobe in children with ADHD compared to controls. The structural abnormalities within the thalamus and the reduced integrity of the white matter tracks between thalamus and other brain regions, as shown from the results of this study, may be the anatomical bases of the impaired cognitive performances in the attention and executive function domains in ADHD.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1111/j.1469-7610.2006.01671.x
发表时间：
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