Selective mitochondrial autophagy during erythroid maturation.
Selective mitochondrial autophagy during erythroid maturation.
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作者：
Chen M;Sandoval H;Wang J
越来越多的证据表明，自噬可以选择性地清除酵母和哺乳动物细胞中的细胞器。我们观察到，在没有NIX的情况下，网织红细胞中自噬小体对线粒体的隔离是有缺陷的。在红系成熟过程中，线粒体膜电位(ΔΨm)的耗散需要NIX。此外，诱导ΔΨm丢失的药物可以恢复自噬小体对线粒体的隔离，并促进NIX−/−红系细胞线粒体的清除。我们的数据表明，线粒体去极化诱导自噬小体识别和隔离线粒体。阐明线粒体选择性自噬的机制不仅有助于我们理解红系成熟的机制，而且可以为通过自噬来控制线粒体的质量以预防衰老、癌症和神经退行性疾病提供更多的见解。
Accumulating evidence suggests that autophagy can be selective in the clearance of organelles in yeast and in mammalian cells. We have observed that the sequestration of mitochondria by autophagosomes was defective in reticulocytes in the absence of Nix. Nixis required for the dissipation of mitochondrial membrane potential (ΔΨm) during erythroid maturation. Moreover, pharmacological agents that induce the loss of ΔΨm can restore the sequestration of mitochondria by autophagosomes and promote mitochondrial clearance in Nix−/− erythroid cells. Our data suggest that mitochondrial depolarization induces recognition and sequestration of mitochondria by autophagosomes. Elucidating the mechanisms underlying selective mitochondrial autophagy not only will help us to understand the mechanisms for erythroid maturation, but also may provide insights into mitochondrial quality control by autophagy in the protection against aging, cancer, and neurodegenerative diseases.
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