Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study.
Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study.
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DOI：
10.1002/mds.28173
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Tan LCS
中科院分区：
文献类型：
--
作者：
Ying AF;Khan S;Wu Y;Jin A;Wong ASY;Tan EK;Yuan JM;Koh WP;Tan LCS
尽管实验证据表明氧化应激与PD的发病机制有关，但流行病学研究提供了饮食抗氧化剂与发生PD风险之间不一致的关联。此外，尚未在任何亚洲人群中进行研究。我们检查了膳食类胡萝卜素（α-胡萝卜素，β-胡萝卜素，番茄红素，β-隐黄素和叶黄素）和维生素（维生素A，C和E）的摄入水平与发展PD的风险之间的关系。我们使用了来自新加坡华人健康研究的数据，这是一项基于人群的前瞻性队列研究，在1993-1998年期间招募了63，257名年龄在45至74岁之间的男性和女性。抗氧化剂的摄入量来自一个有效的半定量食物频率问卷。截至2018年7月31日，通过随访访视、医院记录或PD登记确定了事件病例。风险比和相应的95%置信区间来自多变量考克斯比例风险回归模型，并对其他生活方式和饮食因素进行了调整。在平均19.4年的随访期间，确定了544例PD事件。未发现膳食类胡萝卜素单独或总和存在相关性。总类胡萝卜素的最高四分位数与最低四分位数的风险比为0.98（95%置信区间：0.76-1.28; P趋势= 0.83）。膳食维生素A、C和E与发生PD的风险之间也没有明确的剂量依赖性相关性（所有P趋势≥ 0.10）。具有滞后时间的敏感性分析和排除补充剂的使用并没有实质性地改变结果。饮食中的抗氧化剂，如类胡萝卜素和维生素的摄入量，与新加坡华人患PD的风险无关。版权所有2020作者。Wiley期刊有限责任公司代表国际帕金森病和运动障碍学会出版的运动障碍。
Despite experimental evidence implicating oxidative stress in the pathogenesis of PD, epidemiological studies have provided inconsistent associations between dietary antioxidants and risk of developing PD. Furthermore, no study has been done in any Asian population. We examined the associations for intake levels of dietary carotenoids (α‐carotene, β‐carotene, lycopene, β‐cryptoxanthin, and lutein) and vitamins (vitamin A, C and E) and the risk of developing PD. We used data from the Singapore Chinese Health Study, a population‐based prospective cohort of 63,257 men and women aged 45 to 74 years during enrollment in 1993–1998. Antioxidant intake was derived from a validated semiquantitative food frequency questionnaire. Incident cases were identified through follow‐up interviews, hospital records, or PD registries through 31 July 2018. Hazard ratios and corresponding 95% confidence intervals were derived from multivariable Cox proportional hazard regression models with adjustment for other lifestyle and dietary factors. During an average 19.4 years of follow‐up, 544 incident PD cases were identified. No association was found for dietary carotenoids, individually or summed. Hazard ratio comparing highest to lowest quartile for total carotenoids was 0.98 (95% confidence interval: 0.76–1.28; P trend = 0.83). There were also no clear dose‐dependent associations of dietary vitamins A, C, and E with risk of developing PD (all P trend ≥ 0.10). Sensitive analyses with lag time and excluding supplement use did not materially alter results. Intake of dietary antioxidants, such as carotenoids and vitamins, was not associated with the risk of developing PD in Singaporean Chinese. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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DOI：
10.1073/pnas.0607260103
发表时间：
2006-10-10
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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作者：
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通讯作者：
Esposito, Ennio
影响因子：
7.7
作者：
Johnson, CC;Gorell, JM;Peterson, EL
通讯作者：
Peterson, EL