Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes.
Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes.
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DOI:
10.1016/j.tem.2011.04.001
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发表时间:
2011-08
影响因子:
10.9
通讯作者:
Liu, Libin
中科院分区:
文献类型:
--
作者:
Pilch, Paul F.;Liu, Libin
Caveolae are subdomains of the eukaryotic cell surface that are so-called because they resemble little caves, small omega-shaped invaginations of the plasma membrane into the cytosol. They are present in many cell types and are especially abundant in adipocytes where they have been implicated as playing a role in lipid metabolism. Thus mice and humans lacking caveolae have small adipocytes and exhibit lipodystrophies along with other physiological abnormalities. Here we review the evidence supporting the role of caveolae in adipocyte lipid metabolism in the context of the protein and lipid composition of these structures.
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DOI:
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