Measurement of Thermal Conductivity and Thermal Diffusivity of Porcine and Bovine Kidney Tissues at Supraphysiological Temperatures up to 93 °C.
Measurement of Thermal Conductivity and Thermal Diffusivity of Porcine and Bovine Kidney Tissues at Supraphysiological Temperatures up to 93 °C.
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DOI：
10.3390/s23156865
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发表时间：
2023-08-02
期刊：
影响因子：
--
通讯作者：
Saccomandi P
中科院分区：
文献类型：
--
作者：
Bianchi L;Fiorentini S;Gianella S;Gianotti S;Iadanza C;Asadi S;Saccomandi P
本实验研究旨在研究猪和牛肾组织在更宽的稳态热传导条件下(23.292.8°C)的热特性，与以前的45°C的研究相比，本实验的目的是在温度控制的环境中使用连接到商用热特性分析仪的双针探头测量热特性，即导热系数(K)和热扩散率(α)。测量不确定度的估计与回归模型的评估一起进行，回归模型描述了测量量作为温度的函数的趋势，用于涉及肾脏组织中的热传递的模拟。使用相同的实验瞬变热线技术，对来自两个不同物种，即猪和牛肾组织的同一组织的热性质进行了直接比较，以提供不同选择温度下k和α可能的物种间差异的指示。选择指数拟合曲线对猪肾组织和牛肾组织的k和α的测量值进行内插。结果表明，从室温到水分蒸发开始，组织的k和α值基本保持不变，此后有较显著的增加。事实上，在被调查的最高温度下，即90.0-92.8°C，猪和牛肾组织的平均k值分别比室温下的标称值增加1.2倍和1.3倍。此外，在90.0-92.8℃，猪肾组织和牛肾组织的α平均值分别比基准值增加了1.4倍和1.2倍。在相同的组织温度下，猪肾组织和牛肾组织的热物性之间没有统计学上的显著差异，尽管它们在解剖和结构上存在差异。所提供的量化值和最佳拟合回归模型可用于提高热疗数值模型的预测能力。此外，这项研究可能为改进实现组织模拟体模的方案以及在实验实验室中选择用于生物热传递研究的组织模型提供见解。
This experimental study aimed to characterize the thermal properties of ex vivo porcine and bovine kidney tissues in steady-state heat transfer conditions in a wider thermal interval (23.2–92.8 °C) compared to previous investigations limited to 45 °C. Thermal properties, namely thermal conductivity (k) and thermal diffusivity (α), were measured in a temperature-controlled environment using a dual-needle probe connected to a commercial thermal property analyzer, using the transient hot-wire technique. The estimation of measurement uncertainty was performed along with the assessment of regression models describing the trend of measured quantities as a function of temperature to be used in simulations involving heat transfer in kidney tissue. A direct comparison of the thermal properties of the same tissue from two different species, i.e., porcine and bovine kidney tissues, with the same experimental transient hot-wire technique, was conducted to provide indications on the possible inter-species variabilities of k and α at different selected temperatures. Exponential fitting curves were selected to interpolate the measured values for both porcine and bovine kidney tissues, for both k and α. The results show that the k and α values of the tissues remained rather constant from room temperature up to the onset of water evaporation, and a more marked increase was observed afterward. Indeed, at the highest investigated temperatures, i.e., 90.0–92.8 °C, the average k values were subject to 1.2- and 1.3-fold increases, compared to their nominal values at room temperature, in porcine and bovine kidney tissue, respectively. Moreover, at 90.0–92.8 °C, 1.4- and 1.2-fold increases in the average values of α, compared to baseline values, were observed for porcine and bovine kidney tissue, respectively. No statistically significant differences were found between the thermal properties of porcine and bovine kidney tissues at the same selected tissue temperatures despite their anatomical and structural differences. The provided quantitative values and best-fit regression models can be used to enhance the accuracy of the prediction capability of numerical models of thermal therapies. Furthermore, this study may provide insights into the refinement of protocols for the realization of tissue-mimicking phantoms and the choice of tissue models for bioheat transfer studies in experimental laboratories.
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影响因子：
3.2
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通讯作者：
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