Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice.
Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice.
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DOI：
10.1155/2012/820415
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Tanaka T
中科院分区：
文献类型：
--
作者：
Kawabata K;Tung NH;Shoyama Y;Sugie S;Mori T;Tanaka T
藏红花和栀子花(番红花和栀子花)中含有一种天然类胡萝卜素西红花素，被用作食品着色剂。本研究报道了西红花苷对炎症相关的小鼠结肠癌发生和化学诱导的雄性ICR小鼠结肠炎的潜在抑制作用。在第一个实验中，饲料西红花苷显著抑制偶氮甲烷和葡聚糖硫酸钠诱导的小鼠结肠腺癌的发展。西红花苷还抑制腺癌细胞的增殖和核因子-2κB的免疫组织化学表达，但增加核因子-E2相关因子2的表达。实验二，饲喂西红花4周可抑制DSS诱导的大鼠结肠炎，降低结肠黏膜肿瘤坏死因子α、白介素1β、白介素6、干扰素γ、核因子κB、环氧合酶2和诱导型一氧化氮合酶的表达，增加NRF2mRNA的表达。我们的结果表明，饮食中的西红花苷抑制化学诱导的结肠炎和结肠炎相关的小鼠结肠癌的发生，至少部分是通过抑制炎症和某些促炎细胞因子和诱导性炎症酶的mRNA表达而实现的。因此，西红花苷是预防结肠炎和炎症相关结肠癌发生的候选药物。
A natural carotenoid crocin is contained in saffron and gardenia flowers (crocuses and gardenias) and is used as a food colorant. This study reports the potential inhibitory effects of crocin against inflammation-associated mouse colon carcinogenesis and chemically induced colitis in male ICR mice. In the first experiment, dietary crocin significantly inhibited the development of colonic adenocarcinomas induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) in mice by week 18. Crocin feeding also suppressed the proliferation and immunohistochemical expression of nuclear factor- (NF-) κB but increased the NF-E2-related factor 2 (Nrf2) expression, in adenocarcinoma cells. In the second experiment, dietary feeding with crocin for 4 weeks was able to inhibit DSS-induced colitis and decrease the mRNA expression of tumor necrosis factor α, interleukin- (IL-) 1β, IL-6, interferon γ, NF-κB, cyclooxygenase-2, and inducible nitric oxide synthase in the colorectal mucosa and increased the Nrf2 mRNA expression. Our results suggest that dietary crocin suppresses chemically induced colitis and colitis-related colon carcinogenesis in mice, at least partly by inhibiting inflammation and the mRNA expression of certain proinflammatory cytokines and inducible inflammatory enzymes. Therefore, crocin is a candidate for the prevention of colitis and inflammation-associated colon carcinogenesis.
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影响因子：
6.1
作者：
Carmona, M;Zalacain, A;Alonso, GL
通讯作者：
Alonso, GL
影响因子：
2.6
作者：
Hudcovic, T;Stepánková, R;Tlaskalová-Hogenová, H
通讯作者：
Tlaskalová-Hogenová, H
影响因子：
--
作者：
Akhondzadeh, Shahin;Fallah-Pour, Hasan;Khalighi-Cigaroudi, Farahnaz
通讯作者：
Khalighi-Cigaroudi, Farahnaz
影响因子：
6.8
作者：
El-Beshbishy, Hesham A.;Hassan, Memy H.;Alghaithy, Abdulaziz A. A.
通讯作者：
Alghaithy, Abdulaziz A. A.
DOI：
10.1111/j.1749-6632.2002.tb04671.x
发表时间：
2002-01-01
期刊：
CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS
影响因子：
--
作者：
Bharti, AC;Aggarwal, BB
通讯作者：
Aggarwal, BB