A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.
A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.
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DOI：
10.1126/science.aat8849
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发表时间：
2018-09-28
期刊：
影响因子：
--
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Yu C;Gan H;Serra-Cardona A;Zhang L;Gan S;Sharma S;Johansson E;Chabes A;Xu RM;Zhang Z
How parental histone (H3–H4)2 tetramers, the primary carriers of epigenetic modifications, are transferred onto leading and lagging strands of DNA replication forks for epigenetic inheritance remains elusive. Here, we show that parental (H3–H4)2 tetramers are assembled into nucleosomes onto both leading and lagging strands, with a slight preference for lagging strands. The lagging strand preference increases markedly in cells lacking Dpb3 and Dpb4, two subunits of the leading strand DNA polymerase, Pol s, due to the impairment of parental (H3–H4)2 transfer to leading strands. Dpb3-Dpb4 binds H3–H4 in vitro and participates in the inheritance of heterochromatin. These results indicate that different proteins facilitate the transfer of parental (H3–H4)2 onto leading vs lagging strands, and that Dbp3-Dpb4 plays a significant role in this poorly understood process.
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DOI：
10.1126/science.aaj2114
发表时间：
2017-04-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Wang X;Moazed D
通讯作者：
Moazed D
影响因子：
64.5
作者：
Nakano S;Stillman B;Horvitz HR
通讯作者：
Horvitz HR
影响因子：
10.5
作者：
Eaton, Matthew L.;Galani, Kyriaki;MacAlpine, David M.
通讯作者：
MacAlpine, David M.
影响因子：
56.9
作者：
Laprell, Friederike;Finkl, Katja;Mueller, Juerg
通讯作者：
Mueller, Juerg
影响因子：
16.6
作者：
Burgers PMJ;Kunkel TA
通讯作者：
Kunkel TA