Relationships between serum free fatty acid and pulse pressure amplification in overweight/obese men: insights from exercise training and dietary modification.
Relationships between serum free fatty acid and pulse pressure amplification in overweight/obese men: insights from exercise training and dietary modification.
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DOI：
10.3164/jcbn.17-103
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发表时间：
2018-05
影响因子：
2.4
通讯作者：
Maeda S
中科院分区：
文献类型：
--
作者：
Yoshikawa T;Zempo-Miyaki A;Kumagai H;Myoenzono K;So R;Tsujimoto T;Tanaka K;Maeda S
脉冲压力放大（即，外周与中心脉压的比值）是心血管事件的强预测因子。循环游离脂肪酸是胰岛素抵抗的主要原因，据报道与手臂（从主动脉到肱动脉）的脉压放大有利相关。我们假设，这种矛盾的关系取决于一个评估网站的脉压放大和调查是否血清游离脂肪酸水平与脉压放大在手臂或躯干（从主动脉到股动脉）超重/肥胖男性。在一项横断面研究中，85名男性参与，回归分析显示，血清游离脂肪酸水平与手臂而不是躯干的脉压放大显著且独立相关。在一项纵向研究中，33名男性完成了为期12周的生活方式干预，包括运动训练和饮食调整。生活方式干预引起的血清游离脂肪酸水平的变化与手臂而不是躯干的脉压放大显著相关。这些结果支持了我们的假设，并建议在超重/肥胖男性中应在躯干而不是手臂中测量脉压放大，以简化其解释。
Pulse pressure amplification (i.e., the ratio of peripheral to central pulse pressure) is a strong predictor of cardiovascular events. Circulating free fatty acid, which is a major cause of insulin resistance, has been reported to favorably be associated with pulse pressure amplification in the arm (from the aorta to brachial artery). We hypothesized that this paradoxical relationship depended on an evaluating site of pulse pressure amplification and investigated whether serum free fatty acid level is related to pulse pressure amplification in the arm or trunk (from the aorta to femoral artery) in overweight/obese men. In a cross-sectional study, 85 men participated, and regression analyses revealed that serum free fatty acid level was significantly and independently associated with pulse pressure amplification in the arm but not the trunk. In a longitudinal study, 33 men completed a 12-week lifestyle intervention that involved both exercise training and dietary modification. The lifestyle intervention-induced change in serum free fatty acid level was significantly correlated to that in pulse pressure amplification in the arm but not the trunk. These results support our hypothesis and suggest that pulse pressure amplification should be measured in the trunk instead of the arm in overweight/obese men to simplify its interpretation.
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影响因子：
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DOI：
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DOI：
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期刊：
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