Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality?
Central or peripheral systolic or pulse pressure: which best relates to target organs and future mortality?
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DOI：
10.1097/hjh.0b013e3283220ea4
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发表时间：
2009-03
影响因子：
4.9
通讯作者：
Chen CH
中科院分区：
文献类型：
--
作者：
Wang KL;Cheng HM;Chuang SY;Spurgeon HA;Ting CT;Lakatta EG;Yin FC;Chou P;Chen CH
我们检查了基线时肱动脉和颈动脉中央压力和靶器官指数之间的关系，以及它们与未来死亡率的关系。我们横断面和纵向检查了1272名参与者（47%女性，年龄30-79岁）的中央动脉（校准的颈动脉血压计脉搏）和外周动脉（肱动脉，汞柱血压计）的基线收缩压和脉压与基线左心室质量、颈动脉内膜-中膜厚度、肾小球滤过率、10年全因死亡率和心血管死亡率的关系。左心室质量与中央和外周收缩压的关系比与脉压的关系更强。内膜-中膜厚度和肾小球滤过率与中心压的相关性大于与外周压的相关性。共有130名参与者死亡，其中37人死于心血管疾病。在单变量分析中，所有四个血压变量都能显著预测全因死亡率和心血管死亡率。每个血压变量单独或与另一个血压变量联合输入到多变量模型中。在调整了年龄、性别、心率、体重指数、当前吸烟、血糖、总胆固醇/高密度-脂蛋白-胆固醇比、颈动脉-股动脉脉波速度、左心室质量、内膜-中膜厚度和肾小球滤过率后，只有中央收缩压一致地独立预测心血管死亡率（危险比=1.30 / 10mmhg）。在所有分析中均未观察到显著的性别相互作用。收缩压和脉压与不同的靶器官有不同的关系。中心收缩压在预测心血管死亡率方面比其他血压变量更有价值。
We examined the relationship between brachial and central carotid pressures and target organ indices at baseline, and their association with future mortality. We examined cross-sectionally and longitudinally the relations of baseline systolic and pulse pressures in central (calibrated tonometric carotid pulse) and peripheral (brachial, mercury sphygmomanometer) arteries to baseline left ventricular mass, carotid intima-media thickness, estimated glomerular filtration rate, and 10-year all-cause and cardiovascular mortality in 1272 participants (47% women, aged 30–79 years) from a community of homogeneous Chinese. Left ventricular mass was more strongly related to central and peripheral systolic pressures than pulse pressures. Intima-media thickness and glomerular filtration rate were more strongly related to central pressures than peripheral pressures. A total of 130 participants died, 37 from cardiovascular causes. In univariate analysis, all four blood pressure variables significantly predicted all-cause and cardiovascular mortality. Each blood pressure variable was entered into the multivariate models, both individually and jointly with another blood pressure variable. With adjustment for age, sex, heart rate, body mass index, current smoking, glucose, total cholesterol/high-density-lipoprotein-cholesterol ratio, carotid-femoral pulse wave velocity, left ventricular mass, intima-media thickness, and glomerular filtration rate, only central systolic pressure consistently independently predicted cardiovascular mortality (Hazards ratio=1.30 per 10 mmHg). No significant sex interactions were observed in all analyses. Systolic and pulse pressures relate differently to different target organs. Central systolic pressure is more valuable than other blood pressure variables in predicting cardiovascular mortality.
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影响因子：
37.8
作者：
Devereux, RB;Roman, MJ;Howard, BV
通讯作者：
Howard, BV
影响因子：
8.3
作者：
de Simone, G;Roman, MJ;Devereux, RB
通讯作者：
Devereux, RB
影响因子：
37.8
作者：
Boutouyrie, P;Bussy, C;Laurent, S
通讯作者：
Laurent, S
影响因子：
37.8
作者：
Chen, CH;Ting, CT;Yin, FCP
通讯作者：
Yin, FCP
影响因子：
8.3
作者：
Mosley, William J., II;Greenland, Philip;Lloyd-Jones, Donald M.
通讯作者：
Lloyd-Jones, Donald M.