Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy.
Elevated Expression of Calpain-4 Predicts Poor Prognosis in Patients with Gastric Cancer after Gastrectomy.
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Calpain-4 表达升高预示胃癌患者胃切除术后预后不良
DOI：
10.3390/ijms17101612
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发表时间：
2016-09-27
影响因子：
5.6
通讯作者：
Gu J
中科院分区：
文献类型：
--
作者：
Peng P;Min L;Song S;Zhao J;Li L;Yang C;Shao M;Zhang M;Wu H;Zhang J;Li C;Wang X;Wang H;Qin J;Ruan Y;Gu J
Calpain-4 属于钙依赖性半胱氨酸蛋白酶的钙蛋白酶家族，并作为钙蛋白酶的小调节亚基发挥作用。最近的证据表明 calpain-4 在肿瘤迁移和侵袭中发挥着关键作用。然而，calpain-4 在胃肿瘤发生中的作用仍知之甚少。在此，我们通过免疫组织化学染色对含有 2004 年至 2008 年间 174 名胃癌患者肿瘤样本的组织微阵列进行了 calpain-4 表达检测。采用Kaplan-Meier法比较生存曲线，表达水平与临床病理因素和总生存期相关。我们的数据表明 calpain-4 在胃癌细胞系和原发肿瘤组织中普遍增加。 calpain-4的高表达与血管侵犯、淋巴结转移和晚期TNM（肿瘤淋巴结转移）分期呈正相关。多变量分析确定 calpain-4 是不良预后的独立预后因素。构建了将 calpain-4 表达与其他独立预后指标相结合的预测列线图，与 TNM 分期系统相比，它对胃癌患者的总体生存产生了更好的预后价值。总之，calpain-4 可被视为胃癌临床结果的潜在预后指标。
Calpain-4 belongs to the calpain family of calcium-dependent cysteine proteases, and functions as a small regulatory subunit of the calpains. Recent evidence indicates that calpain-4 plays critical roles in tumor migration and invasion. However, the roles of calpain-4 in gastric tumorigenesis remain poorly understood. Herein, we examined calpain-4 expression by immunohistochemical staining on tissue microarrays containing tumor samples of 174 gastric cancer patients between 2004 and 2008 at a single center. The Kaplan-Meier method was used to compare survival curves, and expression levels were correlated to clinicopathological factors and overall survival. Our data demonstrated that calpain-4 was generally increased in gastric cancer cell lines and primary tumor tissues. High expression of calpain-4 was positively associated with vessel invasion, lymph node metastasis, and advanced TNM (Tumor Node Metastasis) stage. Multivariate analysis identified calpain-4 as an independent prognostic factor for poor prognosis. A predictive nomogram integrating calpain-4 expression with other independent prognosticators was constructed, which generated a better prognostic value for overall survival of gastric cancer patients than a TNM staging system. In conclusion, calpain-4 could be regarded as a potential prognosis indicator for clinical outcomes in gastric cancer.
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影响因子：
12.3
作者：
Robinson MD;Oshlack A
通讯作者：
Oshlack A
影响因子：
5.3
作者：
Arthur, JSC;Elce, JS;Greer, PA
通讯作者：
Greer, PA
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7.7
作者：
Suzuki, K;Hata, S;Sorimachi, H
通讯作者：
Sorimachi, H
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4.8
作者：
Rosenberger, G;Gal, A;Kutsche, K
通讯作者：
Kutsche, K
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11.2
作者：
Rios-Doria, J;Kuefer, R;Day, ML
通讯作者：
Day, ML