Neurological disorders in Northern Tanzania: A 6-year prospective hospital-based case series.
Neurological disorders in Northern Tanzania: A 6-year prospective hospital-based case series.
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DOI：
10.4314/ahs.v22i1.34
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发表时间：
2022-03
影响因子：
1
通讯作者：
Dekker, Marieke C. J.
中科院分区：
文献类型：
--
作者：
Howlett, William P.;Urasa, Sarah J.;Maro, Venance P.;Walker, Richard W.;Kilonzo, Kajiru G.;Howlett, Patrick J.;Dekker, Marieke C. J.
神经系统疾病的负担很大，并因艾滋病毒流行而改变。我们描述了在坦桑尼亚北方一家咨询医院就诊的成人患者的神经系统疾病及其与HIV感染的关系。在这项前瞻性横断面研究中，我们收集了2007年至2013年6年间成人神经科转诊的数据。计算了经年龄和性别调整后的神经系统类别中HIV感染的几率。在2037名参与者中，54.8%为男性，45.2%为女性。参与者的中位年龄为43岁。2037名患者中有992人（48.7%）获得了艾滋病毒筛查结果，其中306人（30.8%）血清反应呈阳性。最常见的神经系统疾病是脑血管疾病（19.9%）、截瘫（13.6%）和周围神经病变（8%）。合并CNS感染占278/2037（13.6%）。HIV感染的校正比值（aOR）最高;脑脓肿（aOR 107，95% CI 35.1-470.4）和脑膜炎/脑炎（aOR 40.1，95%CI 13.6-172.9），而且在脑血管疾病、截瘫、周围神经病、颅神经麻痹、癫痫、大脑疾病、运动障碍、运动神经元疾病和头痛中也升高。坦桑尼亚北方神经系统疾病的主要模式。HIV感染的几率在CNS感染和广泛的非传染性神经系统疾病中最高。
The burden of neurological disorders is large and altered by the HIV epidemic. We describe the pattern of neurological disorders and their association with HIV infection in adult patients attending a consultant hospital in Northern Tanzania. In this prospective cross-sectional study, we collected data on adult neurological referrals over a 6-year period between 2007–13. The odds of HIV infection, across neurological categories adjusted for age and sex, was calculated. Of 2037 participants, 54.8% were male and 45.2% were female. The median age of participants was 43 years. The results for HIV screening were available for 992/2037 (48.7%) patients, of whom 306 (30.8%) were seropositive. The most frequent neurological disorders were cerebrovascular disease (19.9%), paraplegia (13.6%), and peripheral neuropathies (8%). Taken together CNS infection accounted for 278/2037 (13.6%). The adjusted odds (aOR) of HIV infection was highest amongst infections; brain abscesses (aOR 107, 95% CI 35.1–470.4) and meningitis/encephalitis (aOR 40.1, 95% CI 13.6–172.9), but also raised in cerebrovascular disease, paraplegia, peripheral neuropathies, cranial nerve palsies, seizures, cerebllar disorders, movement disorders, motor neuron disease and headache. The main pattern of neurological disorders in Northern Tanzania is presented. The odds of HIV infection was highest in CNS infections and in a wide range of non-communicable neurological disorders.
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影响因子：
3.8
作者：
HOWLETT, WP;NKYA, WM;MISSALEK, WR
通讯作者：
MISSALEK, WR
影响因子：
2.8
作者：
Dekker, M. C. J.;Tieleman, A. A.;Hamel, B. C.
通讯作者：
Hamel, B. C.
影响因子：
2.6
作者：
Diaz, Monica M.;Hu, Xin;Sico, Jason J.
通讯作者：
Sico, Jason J.
影响因子：
5.8
作者：
Bhigjee, Al;Moodley, K.;Romkissoon, K.
通讯作者：
Romkissoon, K.
影响因子：
1.8
作者：
Callixte KT;Clet TB;Jacques D;Faustin Y;François DJ;Maturin TT
通讯作者：
Maturin TT