Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia.
Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia.
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精神安定药对精神分裂症脑葡萄糖代谢改变的影响。
DOI：
10.1001/archpsyc.1988.01800300019002
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发表时间：
1988
影响因子：
--
通讯作者：
J. Cleghorn
中科院分区：
文献类型：
--
作者：
H. Szechtman;C. Nahmias;E. Garnett;Gunther Firnau;Gregory M. Brown;R. Kaplan;J. Cleghorn
本研究通过正电子发射断层扫描检测抗精神病药物治疗时间是否影响脑内[18F]2-氟-2-脱氧-D-葡萄糖利用的区域分布。将两组精神分裂症患者与正常志愿者(n=10)进行比较。一组(n=5)患者接受治疗一年，第二组(n=12)患者服药4~14年(平均+/-SD病程7.4+/-3.4年)。第一组在患者接受第一剂量的抗精神病药物治疗之前也进行了检查。一年的药物治疗不足以改变精神分裂症患者大脑皮质葡萄糖活动的特征，但确实提高了纹状体的活动。服药7.4年也没有改变精神分裂症患者额部多动和后部活动不足的模式，尽管与控制值的偏离似乎没有一年后那么明显。另一方面，在服药7.4年的患者中，纹状体和丘脑的活动可能有更大的增加。因此，接触抗精神病药物的时间可能会影响大脑葡萄糖活动的模式；甚至可能，更长的暴露时间可能会导致其他人注意到的额叶下垂，尽管这可能与疾病持续时间相混淆，作为一个因素。考虑到观察到的皮质葡萄糖活性曲线的生物学意义，我们引入了大脑代谢张力的概念。我们认为，这种张力紊乱可能是精神分裂症的一些症状，并可能与精神分裂症患者大脑发育异常的假说一致。
This study examines whether the duration of treatment with antipsychotic drugs influences the regional distribution of cerebral [18F]2-fluoro-2-deoxy-D-glucose utilization as measured by positron emission tomography. Two groups of schizophrenic patients are compared with normal volunteers (n = 10). One group (n = 5) consisted of patients treated for one year, and the second (n = 12) of patients medicated for four to 14 years (mean +/- SD duration, 7.4 +/- 3.4 years). The first group was also examined before patients received their first dose ever of antipsychotic medication. One year of medication was not sufficient to alter the schizophrenic profile of cerebral cortical glucose activity but did elevate activity of the corpus striatum. Medication for 7.4 years also did not alter the schizophrenic pattern of frontal hyperactivity and posterior hypoactivity, although deviations from control values appeared less marked than after one year. On the other hand, in patients medicated for 7.4 years, there was perhaps an even greater increase in the activity of the corpus striatum and of the thalamus. Thus, duration of exposure to antipsychotic medication may affect the pattern of cerebral glucose activity; possibly, even longer exposure may contribute to the hypofrontality noted by others, although this can be confounded with the duration of illness as a factor. In considering the biological significance of the observed profile of cortical glucose activity, we introduce the concept of cerebral metabolic tone. We suggest that a disturbance of this tonus may account for some symptoms of schizophrenia and could be consistent with the hypothesis of abnormal developmental changes in the brains of schizophrenics.
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慢性精神分裂症和抑郁症局部脑葡萄糖代谢的 PET 测量与脑萎缩的 CAT 测量的比较。
DOI：
10.1176/ajp.143.2.175
发表时间：
1986
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Kling,AS;Metter,EJ;Riege,WH;Kuhl,DE
通讯作者：
Kuhl,DE
影响因子：
--
作者：
Gur,RE;Resnick,SM;Alavi,A;Gur,RC;Caroff,S;Dann,R;Silver,FL;Saykin,AJ;Chawluk,JB;Kushner,M
通讯作者：
Kushner,M
18 名慢性精神分裂症患者代谢活动的现象学相关性。
DOI：
10.1176/ajp.144.2.151
发表时间：
1987
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Volkow,ND;Wolf,AP;VanGelder,P;Brodie,JD;Overall,JE;Cancro,R;Gomez-Mont,F
通讯作者：
Gomez-Mont,F
DOI：
10.1176/ajp.142.5.564
发表时间：
1985-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
A. Wolkin;J. Jaeger;J. Brodie;A. Wolf;J. Fowler;J. Rotrosen;F. Gómez-Mont;R. Cancro
通讯作者：
A. Wolkin;J. Jaeger;J. Brodie;A. Wolf;J. Fowler;J. Rotrosen;F. Gómez-Mont;R. Cancro
影响因子：
--
作者：
R. Gur;S. Resnick;R. Gur;A. Alavi;S. Caroff;M. Kushner;M. Reivich
通讯作者：
R. Gur;S. Resnick;R. Gur;A. Alavi;S. Caroff;M. Kushner;M. Reivich