IgG Antibodies Generation and Side Effects Caused by Ad5-nCoV Vaccine (CanSino Biologics) and BNT162b2 Vaccine (Pfizer/BioNTech) among Mexican Population.
IgG Antibodies Generation and Side Effects Caused by Ad5-nCoV Vaccine (CanSino Biologics) and BNT162b2 Vaccine (Pfizer/BioNTech) among Mexican Population.
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DOI：
10.3390/vaccines9090999
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发表时间：
2021-09-08
期刊：
影响因子：
7.8
通讯作者：
Montero H
中科院分区：
文献类型：
--
作者：
Guzmán-Martínez O;Guardado K;de Guevara EL;Navarro S;Hernández C;Zenteno-Cuevas R;Montero H
SARS-CoV-2 已迅速引发大流行。目前正在推出疫苗来控制病毒传播并防止死亡。使用新平台的紧急疫苗已获得批准。它们在不同人群中的有效性、安全性和免疫原性尚不完全清楚。本研究旨在通过针对蛋白 S 1 亚基 (S1 IgG) 的 IgG 抗体生成来发现信使核糖核酸 (mRNA) BNT162b2 和腺病毒载体 Ad5-nCoV 疫苗的免疫原性，并评估疫苗的副作用。总共包括 115 名疫苗接种者，其中 61 人接种了 BNT162b2 疫苗，54 人接种了 Ad5-nCoV。使用酶联免疫吸附测定 (ELISA) 技术进行 S1 IgG 抗体的测量。 BNT162b2 疫苗在第一剂注射后，80.3% 的参与者产生了 S1 IgG 抗体。服用第二剂后，血清反应呈阳性的参与者人数增加至 98.36%。 Ad5-nCoV 疫苗在 88.89% 的接种者中产生了 S1 IgG 抗体。女性在注射任何一种疫苗时都会产生更多的抗体。疫苗接种没有出现严重的不良反应。总之，并非所有参与者都具有可检测到的 S1 IgG 抗体。 Ad5-nCoV 疫苗出现的血清阴性病例最多。研究的疫苗被证明是安全的。
SARS-CoV-2 has rapidly generated a pandemic. Vaccines are currently being rolled out to control the viral spread and prevent deaths. Emergency vaccines, using new platforms, have been approved. Their effectiveness, safety and immunogenicity in different populations are not fully known. This study aimed to discover the immunogenicity of the messenger ribonucleic acid (mRNA) BNT162b2 and adenovirus vector Ad5-nCoV vaccines through IgG antibody generation against subunit 1 of protein S (S1 IgG) and assess the side effects of the vaccines. A total of 115 vaccinated people were included, 61 of whom received the BNT162b2 vaccine, while 54 received Ad5-nCoV. Measurements of S1 IgG antibodies were carried out using the enzyme-linked immunosorbent assay (ELISA) technique. The BNT162b2 vaccine generated S1 IgG antibodies in 80.3% of the participants after the first dose. The number of seropositive participants increased to 98.36% with the administration of the second dose. The Ad5-nCoV vaccine generated S1 IgG antibodies in 88.89% of those vaccinated. Women generated more antibodies when administered either vaccine. There were no serious adverse effects from vaccination. In conclusion, not all participants had detectable S1 IgG antibodies. The Ad5-nCoV vaccine presented the most seronegative cases. The studied vaccines were shown to be safe.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
5.4
作者：
Figueiredo-Campos P;Blankenhaus B;Mota C;Gomes A;Serrano M;Ariotti S;Costa C;Nunes-Cabaço H;Mendes AM;Gaspar P;Pereira-Santos MC;Rodrigues F;Condeço J;Escoval MA;Santos M;Ramirez M;Melo-Cristino J;Simas JP;Vasconcelos E;Afonso Â;Veldhoen M
通讯作者：
Veldhoen M
影响因子：
19
作者：
Harvala, Heli;Mehew, Jennifer;Zambon, Maria
通讯作者：
Zambon, Maria
影响因子：
4.6
作者：
Elezkurtaj S;Greuel S;Ihlow J;Michaelis EG;Bischoff P;Kunze CA;Sinn BV;Gerhold M;Hauptmann K;Ingold-Heppner B;Miller F;Herbst H;Corman VM;Martin H;Radbruch H;Heppner FL;Horst D
通讯作者：
Horst D
影响因子：
64.8
作者：
Mulligan, Mark J.;Lyke, Kirsten E.;Jansen, Kathrin U.
通讯作者：
Jansen, Kathrin U.