The Itch-Scratch Cycle: A Neuroimmune Perspective.
The Itch-Scratch Cycle: A Neuroimmune Perspective.
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DOI：
10.1016/j.it.2018.10.001
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发表时间：
2018-12
影响因子：
16.8
通讯作者：
Kim BS
中科院分区：
文献类型：
--
作者：
Mack MR;Kim BS
Relentless, repetitive itching and scratching is a debilitating feature of many chronic inflammatory skin disorders such as atopic dermatitis. While well known clinically, this itch–scratch cycle has historically lacked in-depth mechanistic understanding. However, recent advances at the interface of itch neurobiology and skin immunology have shed new light on this phenomenon. In this review, we highlight recent advances in our understanding of the neuroimmunology of chronic itch centered around three key points of entry into the itch–scratch cycle: the epithelial barrier, the immune system, and the peripheral nervous system. Furthermore, we explore novel neuro-epithelial-immune interactions that may represent promising therapeutic paradigms.
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DOI：
10.1084/jem.20082242
发表时间：
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期刊：
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影响因子：
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