Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer's disease.
Retained capacity for perceptual learning of degraded speech in primary progressive aphasia and Alzheimer's disease.
复制标题
DOI：
10.1186/s13195-018-0399-2
复制
发表时间：
2018-07-25
期刊：
影响因子：
--
通讯作者：
Warren JD
中科院分区：
文献类型：
--
作者：
Hardy CJD;Marshall CR;Bond RL;Russell LL;Dick K;Ariti C;Thomas DL;Ross SJ;Agustus JL;Crutch SJ;Rohrer JD;Bamiou DE;Warren JD
退化语音的处理是一个很有前途的模型，在具有挑战性的听力条件下，核心听觉缺陷和知觉学习和大脑可塑性的主要痴呆症的剩余能力的理解通信。我们比较了26例原发性进行性失语症患者（非流利，语义和logopenic变体），10例典型阿尔茨海默病患者和17例健康对照组的正弦波退化语音的处理。参与者被要求识别更可预测（三位数）或更不可预测（地名）的正弦波单词。每次会话中识别性能的变化指示感知学习。退化的语音处理的神经解剖学协会进行了评估，使用基于体素的形态。非流利和logopenic进行性失语症和典型的阿尔茨海默病患者表现出受损的识别正弦波数，而所有的综合征组表现出受损的识别正弦波的地名。一个显着的整体识别优势，数字超过地名显示了典型的阿尔茨海默氏病患者，语义进行性失语症患者和健康对照组的参与者。所有综合征组均表现出对正弦波数的自发知觉学习效应。对于合并的患者队列，在一个分布式的左半球网络中识别出灰质相关性，该网络超出了经典的语音处理皮层。这些研究结果表明，在痴呆综合征的听觉感知学习能力的弹性，尽管受损的感知解码退化的语音和减少预测整合的语义知识。这项工作对神经退行性疾病的动态感觉处理和可塑性的神经生物学以及开发新的生物标志物和治疗干预措施具有重要意义。本文的在线版本（10.1186/s13195-018-0399-2）包含补充材料，可供授权用户使用。
Processing of degraded speech is a promising model for understanding communication under challenging listening conditions, core auditory deficits and residual capacity for perceptual learning and cerebral plasticity in major dementias. We compared the processing of sine-wave-degraded speech in 26 patients with primary progressive aphasia (non-fluent, semantic, and logopenic variants), 10 patients with typical Alzheimer’s disease and 17 healthy control subjects. Participants were required to identify sine-wave words that were more predictable (three-digit numbers) or less predictable (place names). The change in identification performance within each session indexed perceptual learning. Neuroanatomical associations of degraded speech processing were assessed using voxel-based morphometry. Patients with non-fluent and logopenic progressive aphasia and typical Alzheimer’s disease showed impaired identification of sine-wave numbers, whereas all syndromic groups showed impaired identification of sine-wave place names. A significant overall identification advantage for numbers over place names was shown by patients with typical Alzheimer’s disease, patients with semantic progressive aphasia and healthy control participants. All syndromic groups showed spontaneous perceptual learning effects for sine-wave numbers. For the combined patient cohort, grey matter correlates were identified across a distributed left hemisphere network extending beyond classical speech-processing cortices. These findings demonstrate resilience of auditory perceptual learning capacity across dementia syndromes, despite variably impaired perceptual decoding of degraded speech and reduced predictive integration of semantic knowledge. This work has implications for the neurobiology of dynamic sensory processing and plasticity in neurodegenerative diseases and for development of novel biomarkers and therapeutic interventions. The online version of this article (10.1186/s13195-018-0399-2) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
2.6
作者：
Hailstone JC;Ridgway GR;Bartlett JW;Goll JC;Crutch SJ;Warren JD
通讯作者：
Warren JD
影响因子：
14.5
作者：
Crutch, SJ;Warrington, EK
通讯作者：
Warrington, EK
影响因子：
2.6
作者：
Clark, Camilla N.;Nicholas, Jennifer M.;Warren, Jason D.
通讯作者：
Warren, Jason D.
影响因子：
4.2
作者：
Golden, Hannah L.;Agustus, Jennifer L.;Warren, Jason D.
通讯作者：
Warren, Jason D.
影响因子：
5.7
作者：
Golestani, Narly;Hervais-Adelman, Alexis;Scott, Sophie K.
通讯作者：
Scott, Sophie K.