Quantitative assessment of female sexual motivation in the rat: Hormonal control of motivation.
Quantitative assessment of female sexual motivation in the rat: Hormonal control of motivation.
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DOI：
10.1016/j.jneumeth.2011.11.017
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发表时间：
2012-03-15
影响因子：
3
通讯作者：
Becker, Jill B.
中科院分区：
文献类型：
--
作者：
Cummings, Jennifer A.;Becker, Jill B.
虽然在过去的几十年里，关于女性性行为的神经和荷尔蒙控制已经获得了大量的信息，但关于女性性动机的这些机制的文献一直很少。我们认为，这其中的一个原因是缺乏一个标准化的范例来量化女性的性动机，同时允许发生性行为互动。在这里，我们描述了一种利用操作员反应(戳鼻子)来量化女性性动机的双腔装置。在测试过程中，女性会展示鼻子戳来接近性行为活跃的男性，并被允许与之交配。因此，这种仪器允许检查性行为，并通过评估女性在固定间隔内为接近男性而展示的鼻子戳的次数来量化性动机。我们报告说，荷尔蒙启动显着增加了女性的性动机，这是由她为接近男性而展示的鼻子戳的次数所表明的。此外，与没有荷尔蒙刺激的雌性相比，荷尔蒙刺激的雌性进入雄性隔间的时间更短，与雄性直接接触的时间更长。相比之下，当女性没有荷尔蒙刺激时，她们花更多的时间在男性的视线之外，而不是男性的视线。这一范式将有助于推进女性性动机的研究，为在允许发生性行为的同时对女性性动机进行量化评估提供一种方法。
While a good deal of information has been garnered in the last few decades regarding the neural and hormonal control of female sexual behavior, literature elucidating these mechanisms with respect to female sexual motivation has been scarce. We believe that one reason for this is the lack of a standardized paradigm that will quantify female sexual motivation while allowing for sexual interaction to occur. Here we describe a two-chambered apparatus that utilizes operant responding (nose poking) to quantify female sexual motivation. During the test, the female exhibits nose pokes to gain access to a sexually active male, with whom she is allowed to mate. Therefore, this apparatus allows for examination of sexual behavior as well as quantification of sexual motivation by assessing the number of nose pokes the female will exhibit within a fixed interval to gain access to the male. We report that hormone priming significantly increases sexual motivation in the female as indicated by the number of nose pokes she will exhibit to gain access to the male. Additionally, hormone primed females enter the male compartment after a shorter period and spend more time in direct contact with the male compared to when they are not hormone primed. In contrast, when females are not hormone primed they spend more time in view, but out of reach, of the male. This paradigm will help to advance the study of female sexual motivation, providing a method for quantifiable assessment of female sexual motivation while allowing for sexual activity to occur.
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影响因子：
1.3
作者：
MCCLINTOCK, MK;ADLER, NT
通讯作者：
ADLER, NT
影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
ANISKO, JJ
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--
作者：
BEACH, FA;LEVINSON, G
通讯作者：
LEVINSON, G