Bidirectional modulation of substantia nigra activity by motivational state.
Bidirectional modulation of substantia nigra activity by motivational state.
复制标题
DOI：
10.1371/journal.pone.0071598
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Yin HH
中科院分区：
文献类型：
--
作者：
Rossi MA;Fan D;Barter JW;Yin HH
基底神经节的一个主要输出核是网状黑质，它将gaba能投射到脑干和丘脑核。GABA神经元与附近的多巴胺能神经元相互连接，多巴胺能神经元主要投射到基底节区，基底节区是一组对目标导向行为至关重要的皮质下核。本研究考察了动机状态对黑质网状部GABA神经元和邻近的致密部多巴胺能（DA）神经元活性的影响。这两种类型的神经元对预测食物奖励的提示都表现出短潜伏期的爆发。当老鼠通过反复食用食物颗粒而感到饱足时，一类神经元减少了线索引发的放电，而另一类神经元则逐渐增加了放电。在测试前的消失或预喂食显著地减少了相反应和它们的动机调节。这些结果表明，与当前动机状态相关的信号双向调节黑质DA和GABA神经元的行为和相反应的大小。
A major output nucleus of the basal ganglia is the substantia nigra pars reticulata, which sends GABAergic projections to brainstem and thalamic nuclei. The GABAergic (GABA) neurons are reciprocally connected with nearby dopaminergic neurons, which project mainly to the basal ganglia, a set of subcortical nuclei critical for goal-directed behaviors. Here we examined the impact of motivational states on the activity of GABA neurons in the substantia nigra pars reticulata and the neighboring dopaminergic (DA) neurons in the pars compacta. Both types of neurons show short-latency bursts to a cue predicting a food reward. As mice became sated by repeated consumption of food pellets, one class of neurons reduced cue-elicited firing, whereas another class of neurons progressively increased firing. Extinction or pre-feeding just before the test session dramatically reduced the phasic responses and their motivational modulation. These results suggest that signals related to the current motivational state bidirectionally modulate behavior and the magnitude of phasic response of both DA and GABA neurons in the substantia nigra.
登录
查看更多内容
通过基础神经节电路的光遗传控制对帕金森运动行为的调节。
影响因子：
64.8
作者：
通讯作者：
--
神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
7.4
作者：
Narayanan, Nandakumar S.;Guarnieri, Douglas J.;DiLeone, Ralph J.
通讯作者：
DiLeone, Ralph J.