NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.
NK1.1+ cells and IL-22 regulate vaccine-induced protective immunity against challenge with Mycobacterium tuberculosis.
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DOI：
10.4049/jimmunol.1102833
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发表时间：
2012-07-15
期刊：
影响因子：
--
通讯作者：
Vankayalapati R
中科院分区：
文献类型：
--
作者：
Dhiman R;Periasamy S;Barnes PF;Jaiswal AG;Paidipally P;Barnes AB;Tvinnereim A;Vankayalapati R
We previously found that human NK cells lyse M. tuberculosis (M. tb)-infected monocytes and alveolar macrophages, and upregulate CD8+ T-cell responses. We also found that human NK cells produce IL-22, which inhibits intracellular growth of M. tb, and that NK cells lyse M. tb-expanded CD4+CD25+FoxP3+ T regulatory cells (Tregs). To determine the role of NK cells during the protective immune response to vaccination in vivo, we studied the NK cell and T-cell responses in a mouse model of vaccination with Bacillus Calmette-Guérin (BCG), followed by challenge with virulent M. tb H37Rv. BCG vaccination enhanced the number of IFN-γ- IL-22-producing NK cells. Depletion of NK1.1+ cells at the time of BCG vaccination increased the number of immunosuppressive Tregs (CD4+CD25hi, 95% Foxp3+) after challenge with M. tb H37Rv, and NK1.1+ cells lysed expanded but not natural Tregs in BCG-vaccinated mice. Depletion of NK1.1+ cells at the time of BCG vaccination also increased the bacillary burden and reduced T-cell responses after challenge with M. tb H37Rv. IL-22 at the time of vaccination reversed these effects and enhanced antigen-specific CD4+ cell responses in BCG-vaccinated mice after challenge with M. tb H37Rv. Our study provides the first evidence that NK1.1+ cells and IL-22 contribute to the efficacy of vaccination against microbial challenge.
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DOI：
10.1016/j.tube.2011.06.009
发表时间：
2011-11
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
--
作者：
Matthews K;Wilkinson KA;Kalsdorf B;Roberts T;Diacon A;Walzl G;Wolske J;Ntsekhe M;Syed F;Russell J;Mayosi BM;Dawson R;Dheda K;Wilkinson RJ;Hanekom WA;Scriba TJ
通讯作者：
Scriba TJ
影响因子：
20.3
作者：
Bluman, EM;Schnier, GS;Caligiuri, MA
通讯作者：
Caligiuri, MA
独特的，特定的IL-17-和IL-22产生的CD4+ T细胞子集有助于人类抗细菌免疫反应。
影响因子：
4.4
作者：
Scriba, Thomas J.;Kalsdorf, Barbara;Abrahams, Deborah-Ann;Isaacs, Fatima;Hofmeister, Jessica;Black, Gillian;Hassan, Hisham Y.;Wilkinson, Robert J.;Walzl, Gerhard;Gelderbloem, Sebastian J.;Mahomed, Hassan;Hussey, Gregory D.;Hanekom, Willem A.
通讯作者：
Hanekom, Willem A.
影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
DOI：
10.4049/jimmunol.0903357
发表时间：
2010-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hall LJ;Clare S;Dougan G
通讯作者：
Dougan G