Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis.
Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis.
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DOI：
10.1001/jamaneurol.2013.573
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发表时间：
2013-01
期刊：
影响因子：
29
通讯作者：
Calabresi, Peter A.
中科院分区：
文献类型：
--
作者：
Saidha, Shiv;Sotirchos, Elias S.;Oh, Jiwon;Syc, Stephanie B.;Seigo, Michaela A.;Shiee, Navid;Eckstein, Chistopher;Durbin, Mary K.;Oakley, Jonathan D.;Meyer, Scott A.;Frohman, Teresa C.;Newsome, Scott;Ratchford, John N.;Balcer, Laura J.;Pham, Dzung L.;Crainiceanu, Ciprian M.;Frohman, Elliot M.;Reich, Daniel S.;Calabresi, Peter A.
为了确定常规光学相干断层扫描（OCT）和分割衍生光学相干断层扫描（OCT）之间的关系，在多发性硬化症中，视网膜层厚度测量与颅内体积（头部大小的替代品）和脑亚结构体积有关。横断面研究：84名多发性硬化症患者和24名健康对照，高清光谱域OCT常规和自动分割衍生的离散视网膜层厚度，无视神经炎病史的多发性硬化症眼的视网膜乳头周围神经纤维层和复合神经节细胞层+内丛状层（GCIP）厚度与皮质灰质（p=0.01和p=0.04）和尾状核体积（p=0.04和p=0.03）相关。在没有视神经炎病史的眼睛中，内核层厚度与flair病变体积相关（p=0.007），与复发-缓解型多发性硬化症中正常的白质体积负相关（p=0.005）。由于在多发性硬化症患者和健康对照中发现颅内容量与多项OCT指标相关，并且已知与脑亚结构体积相关，因此所有OCT-脑亚结构关系都根据颅内容量进行了调整。视网膜测量反映了多发性硬化症的整体中枢神经系统病理，离散视网膜层的厚度似乎与不同的中枢神经系统过程有关。此外，OCT测量似乎与多发性硬化症和健康对照的颅内体积相关，这是一个重要的意外因素，在先前的研究中未考虑到乳头周围视网膜神经纤维层厚度与脑亚结构体积之间的关系。
To determine the relationships between conventional and segmentation-derived optical coherence tomography (OCT) retinal layer thickness measures with intracranial volume (a surrogate of head size), and brain-substructure volumes in multiple sclerosis. Cross-sectional study Johns Hopkins, Baltimore, Maryland 84 multiple sclerosis patients and 24 healthy controls High-definition spectral-domain OCT conventional and automated segmentation-derived discrete retinal layer thicknesses, and 3-Tesla MRI brain-substructure volumes Peripapillary retinal nerve fiber layer and composite ganglion cell layer + inner plexiform layer (GCIP) thicknesses in multiple sclerosis eyes without a history of optic neuritis were associated with cortical-gray matter (p=0.01 and p=0.04 respectively) and caudate volumes (p=0.04 and p=0.03 respectively). Inner nuclear layer thickness, also in eyes without a prior history of optic neuritis, was associated with FLAIR-lesion volume (p=0.007), and inversely associated with normal appearing white matter volume (p=0.005) in relapsing-remitting multiple sclerosis. As intracranial volume was found to be related with several of the OCT measures in multiple sclerosis patients and healthy controls, and is already known to be associated with brain-substructure volumes, all OCT-brain-substructure relationships were adjusted for intracranial volume. Retinal measures reflect global central nervous system pathology in multiple sclerosis, with thicknesses of discrete retinal layers each appearing to be associated with distinct central nervous system processes. Moreover, OCT measures appear to correlate with intracranial volume in multiple sclerosis and healthy controls, an important unexpected factor unaccounted for in prior studies examining the relationships between peripapillary retinal nerve fiber layer thickness and brain-substructure volumes.
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