The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis
The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis
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缺氧诱导因子1亚基α基因rs2057482多态性与癌症风险之间的关联：荟萃分析
DOI：
10.1186/s12885-019-6329-2
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发表时间：
2019-11
期刊：
影响因子：
3.8
通讯作者：
Chen Wei-Xian
中科院分区：
文献类型：
--
作者：
Wu Li-Fang;Xu Gui-Ping;Zhao Qing;Zhou Li-Jing;Wang Ding;Chen Wei-Xian
研究背景低氧诱导因子1 α亚基（HIF 1A）基因rs2057482多态性与多种癌症的发病风险相关，但这种相关性尚未得到明确证实。我们进行了荟萃分析，以确定是否rs2057482与整体癌症risk.MethodsThe PubMed，Embase，和Web的科学数据库进行了搜索的潜在研究之间的关联rs2057482和癌症的风险。从选定的研究中提取癌症病例和对照的基因型频率数据。比值比（OR）和相应的95%置信区间（CI）进行计算，以确定强度的association.ResultsThe荟萃分析显示之间的关联rs2057482多态性和整体癌症风险。然而，种族分层分析没有显示任何显着的关联rs2057482和癌症风险在亚洲population.ConclusionsThe rs2057482多态性与整体癌症风险降低，根据目前可用的研究。然而，这一结论需要通过进一步精心设计的流行病学研究来验证，这些研究检查了不同的癌症类型和更多的受试者。
BackgroundThe rs2057482 polymorphism in thehypoxia inducible factor 1 subunit alpha (HIF1A)gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitively confirmed. We performed this meta-analysis to determine whether rs2057482 is associated with overall cancer risk.MethodsThe PubMed, Embase, and Web of Science databases were searched for the potential studies about the association between the rs2057482 and cancer risk. The data of genotype frequencies in cases with cancer and controls were extracted from the selected studies. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated to determine the strength of the associations.ResultsThe meta-analysis showed an association between the rs2057482 polymorphism and overall cancer risk. However, a stratified analysis of ethnicity did not show any significant association between rs2057482 and cancer risk in the Asian population.ConclusionsThe rs2057482 polymorphism was associated with decreased overall cancer risk, based on the currently available studies. However, this conclusion needs verification by further well-designed epidemiology studies that examine different cancer types and more subjects.
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