Dynamic changes of serum SARS-coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge.
Dynamic changes of serum SARS-coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge.
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DOI：
10.1186/1465-9921-6-5
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发表时间：
2005-01-08
影响因子：
5.8
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Xie L;Liu Y;Fan B;Xiao Y;Tian Q;Chen L;Zhao H;Chen W
本研究的目的是检查因严重急性呼吸系统综合征（SARS）住院的患者在出院后一年内的恢复情况。研究的参数包括血清SARS冠状病毒（SARS-CoV）IgG抗体水平，肺功能测试和成像数据，以评估肺纤维化的变化。此外，我们探讨了股骨头坏死的发病率在一些个人从SARS康复。本研究的对象是中国北京383例临床诊断的SARS患者。在出院后的12个月内，他们在中国人民解放军总医院定期检测血清SARS-CoV IgG抗体水平和肺功能，并接受胸部X线和/或高分辨率计算机断层扫描（HRCT）检查。发现肺弥散异常（一氧化碳转移系数[DLCO] <预测值[pred]的80%）的个体在随访阶段接受定期肺功能检查和HRCT检查，以记录其肺部状况的变化。一些主诉关节疼痛的患者接受了股骨头磁共振成像（MRI）检查。在所有受试者中，81.2%（311/383）的患者血清SARS-CoV IgG检测阳性。在检测阳性的患者中，27.3%（311例患者中的85例）患有肺弥散异常（DLCO <80%pred），21.5%（311例患者中的67例）表现出肺纤维化改变。在为期12个月的研究中，所有40例肺弥散异常患者的肺功能和肺纤维化均有所改善。在接受MRI检查的患者中，23.1%（78例患者中的18例）显示股骨头坏死迹象。在一些个体中缺乏血清阳性SARS-CoV表明，在本研究纳入的受试者中可能存在一些误诊病例。在检测阳性的患者中，血清SARS-CoV IgG抗体水平在出院后的12个月内显著下降。此外，我们发现患有肺纤维化的个体表现出一些自发性恢复。最后，一些受试者发生股骨头坏死。
The intent of this study was to examine the recovery of individuals who had been hospitalized for severe acute respiratory syndrome (SARS) in the year following their discharge from the hospital. Parameters studied included serum levels of SARS coronavirus (SARS-CoV) IgG antibody, tests of lung function, and imaging data to evaluate changes in lung fibrosis. In addition, we explored the incidence of femoral head necrosis in some of the individuals recovering from SARS. The subjects of this study were 383 clinically diagnosed SARS patients in Beijing, China. They were tested regularly for serum levels of SARS-CoV IgG antibody and lung function and were given chest X-rays and/or high resolution computerized tomography (HRCT) examinations at the Chinese PLA General Hospital during the 12 months that followed their release from the hospital. Those individuals who were found to have lung diffusion abnormities (transfer coefficient for carbon monoxide [DLCO] < 80% of predicted value [pred]) received regular lung function tests and HRCT examinations in the follow-up phase in order to document the changes in their lung condition. Some patients who complained of joint pain were given magnetic resonance imaging (MRI) examinations of their femoral heads. Of all the subjects, 81.2% (311 of 383 patients) tested positive for serum SARS-CoV IgG. Of those testing positive, 27.3% (85 of 311 patients) were suffering from lung diffusion abnormities (DLCO < 80% pred) and 21.5% (67 of 311 patients) exhibited lung fibrotic changes. In the 12 month duration of this study, all of the 40 patients with lung diffusion abnormities who were examined exhibited some improvement of lung function and fibrosis detected by radiography. Of the individuals receiving MRI examinations, 23.1% (18 of 78 patients) showed signs of femoral head necrosis. The lack of sero-positive SARS-CoV in some individuals suggests that there may have been some misdiagnosed cases among the subjects included in this study. Of those testing positive, the serum levels of SARS-CoV IgG antibody decreased significantly during the 12 months after hospital discharge. Additionally, we found that the individuals who had lung fibrosis showed some spontaneous recovery. Finally, some of the subjects developed femoral head necrosis.
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