Guest-adaptable and water-stable peptide-based porous materials by imidazolate side chain control.
Guest-adaptable and water-stable peptide-based porous materials by imidazolate side chain control.
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DOI：
10.1002/anie.201307074
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发表时间：
2014-01-03
影响因子：
16.6
通讯作者：
Rosseinsky, Matthew J.
中科院分区：
文献类型：
--
作者：
Katsoulidis, Alexandros P.;Park, Kyo Sung;Antypov, Dmytro;Marti-Gastaldo, Carlos;Miller, Gary J.;Warren, John E.;Robertson, Craig M.;Blanc, Frederic;Darling, George R.;Berry, Neil G.;Purton, John A.;Adams, Dave J.;Rosseinsky, Matthew J.
以Zn2+和天然二肽肌肽（β-丙烯酰- l-组氨酸）为原料合成了基于多肽的多孔三维骨架ZnCar。与先前的扩展肽网络不同，组氨酸残基的咪唑侧链被去质子化以提供咪唑锌链，其键合类似于多孔材料的沸石咪唑骨架（ZIF）家族。ZnCar具有永久微孔隙，其表面积为448 m2 g−1，其孔隙为具有5个Å开口的一维通道，具有典型的手性形状。这种化合物在有机溶剂和水中具有化学稳定性。单晶x射线衍射（XRD）表明，由于His-β-Ala主链的扭转柔韧性，ZnCar骨架能够适应MeOH和H2O客体，同时保留了咪唑锌链所赋予的刚性。肌肽采用的构象是由与其他二肽和客体形成的氢键驱动的，从而允许观察到的结构转变。
The peptide-based porous 3D framework, ZnCar, has been synthesized from Zn2+ and the natural dipeptide carnosine (β-alanyl-L-histidine). Unlike previous extended peptide networks, the imidazole side chain of the histidine residue is deprotonated to afford Zn–imidazolate chains, with bonding similar to the zeolitic imidazolate framework (ZIF) family of porous materials. ZnCar exhibits permanent microporosity with a surface area of 448 m2 g−1, and its pores are 1D channels with 5 Å openings and a characteristic chiral shape. This compound is chemically stable in organic solvents and water. Single-crystal X-ray diffraction (XRD) showed that the ZnCar framework adapts to MeOH and H2O guests because of the torsional flexibility of the main His-β-Ala chain, while retaining the rigidity conferred by the Zn–imidazolate chains. The conformation adopted by carnosine is driven by the H bonds formed both to other dipeptides and to the guests, permitting the observed structural transformations.
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影响因子：
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作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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