Role of the Hedgehog Signaling Pathway in Regulating the Behavior of Germline Stem Cells.
Role of the Hedgehog Signaling Pathway in Regulating the Behavior of Germline Stem Cells.
复制标题
Hedgehog信号通路在调节生殖干细胞行为中的作用
DOI：
10.1155/2017/5714608
复制
发表时间：
2017
影响因子：
4.3
通讯作者：
Pan Z
中科院分区：
文献类型：
--
作者：
Li S;Wang M;Chen Y;Wang W;Wu J;Yu C;Zheng Y;Pan Z
生殖系干细胞（GSC）是负责配子产生的成体干细胞，包括精原干细胞（SSC）和卵巢生殖系干细胞（OGSC）。GSC位于性腺中称为生态位的专门微环境中。近年来的研究表明，微生态位中的多种信号共同调控GSCs的增殖和分化，对生殖功能具有重要意义。以往的研究表明，刺猬（Hh）信号通路参与了各种干细胞的增殖和分化，包括果蝇和雄性哺乳动物的GSC。此外，哺乳动物OGSC的发现挑战了哺乳动物出生后初级卵泡数量固定的传统观点，这对雌性哺乳动物的生殖能力和生殖细胞相关疾病的治疗具有重要意义。同时，Hh信号通路是否参与OGSC的行为调控仍有待进一步研究。本文就Hh信号通路在GSCs行为调控中的作用作一综述。最后，对今后的研究提出了一些建议。
Germline stem cells (GSCs) are adult stem cells that are responsible for the production of gametes and include spermatogonial stem cells (SSCs) and ovarian germline stem cells (OGSCs). GSCs are located in a specialized microenvironment in the gonads called the niche. Many recent studies have demonstrated that multiple signals in the niche jointly regulate the proliferation and differentiation of GSCs, which is of significance for reproductive function. Previous studies have demonstrated that the hedgehog (Hh) signaling pathway participates in the proliferation and differentiation of various stem cells, including GSCs in Drosophila and male mammals. Furthermore, the discovery of mammalian OGSCs challenged the traditional opinion that the number of primary follicles is fixed in postnatal mammals, which is of significance for the reproductive ability of female mammals and the treatment of diseases related to germ cells. Meanwhile, it still remains to be determined whether the Hh signaling pathway participates in the regulation of the behavior of OGSCs. Herein, we review the current research on the role of the Hh signaling pathway in mediating the behavior of GSCs. In addition, some suggestions for future research are proposed.
登录
查看更多内容
DOI：
10.1083/jcb.201212094
发表时间：
2013-05-27
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hartman TR;Strochlic TI;Ji Y;Zinshteyn D;O'Reilly AM
通讯作者：
O'Reilly AM
DOI：
10.5713/ajas.15.0797
发表时间：
2016-08
期刊：
Asian-Australasian journal of animal sciences
影响因子：
--
作者：
de Castro FC;Cruz MH;Leal CL
通讯作者：
Leal CL
影响因子：
4.8
作者：
Buglino, John A.;Resh, Marilyn D.
通讯作者：
Resh, Marilyn D.
影响因子：
3.6
作者：
Kroft, TL;Patterson, J;Goldberg, E
通讯作者：
Goldberg, E
DOI：
10.1146/annurev-cellbio-100913-013344
发表时间：
2015
影响因子：
11.3
作者：
Greenspan LJ;de Cuevas M;Matunis E
通讯作者：
Matunis E