Epidemiology of Chronic Urticaria in Korea Using the Korean Health Insurance Database, 2010-2014.
Epidemiology of Chronic Urticaria in Korea Using the Korean Health Insurance Database, 2010-2014.
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DOI：
10.4168/aair.2017.9.5.438
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Ye YM
中科院分区：
文献类型：
--
作者：
Lee N;Lee JD;Lee HY;Kang DR;Ye YM
关于慢性荨麻疹（CU）的流行病学研究很少。我们的目的是调查CU的患病率，并在一项基于全国人口的研究中描述该疾病的人口统计学和药物模式。2010 - 2014年的荨麻疹数据（国际疾病分类第10版L50）来自韩国健康保险审查评估院。设计用于评估抗组胺药处方声明的算法用于识别CU。CU的粗患病率为2256.5 / 10万人-年，且呈逐年上升趋势。年龄标准化的CU患病率女性明显高于男性（2466.8 vs 1819.2 / 100000人年，P<0.001）。65岁以上的老年人患病率最高，10-29岁年龄组患病率最低。CU的中位持续时间为591天，61.9%的患者症状持续至少1年。胃肠道疾病是成人中最常见的合并症，而过敏性鼻炎和普通感冒在CU患儿中更为普遍。大约三分之一的CU患者单独服用抗组胺药，70%的患者同时服用抗组胺药和全身皮质类固醇。0.02%的CU患者使用环孢素。本研究概述了最近的纵向流行病学数据的流行CU在韩国。鉴于索赔数据使用的局限性，包括CU没有特定的疾病代码，药物索赔与荨麻疹症状之间可能存在不一致，有必要进一步调查以描述CU患者的确切流行病学概况。
There are very few epidemiological studies on chronic urticaria (CU). We aimed to investigate the prevalence of CU and to depict demographics and medication patterns for the disease in a nationwide population-based study. Data on urticaria (L50 of the International Classification of Diseases, 10th revision) from 2010 to 2014 were obtained from the Korean Health Insurance Review and Assessment Service. Algorithms designed to evaluate prescription drug claims for antihistamines were applied to identify CU. The crude prevalence of CU was 2,256.5 per 100,000 person-years and tended to increase every year. The age-standardized prevalence of CU was significantly higher in females than in males (2,466.8 vs 1,819.2 per 100,000 person-years, P<0.001). Age-specific prevalence was highest for older adults over the age of 65 years and lowest for ages 10-29 years. The median duration of CU was 591 days, and symptoms lasted for at least 1 year in 61.9% of patients. Gastrointestinal disease was the most common comorbidity in adults, whereas allergic rhinitis and common cold were more prevalent in children with CU. Around a third of CU patients were taking antihistamine treatment alone, and 70% were treated with both antihistamines and systemic corticosteroids. Cyclosporine was prescribed for 0.02% of CU patients. The present study outlines recent longitudinal epidemiological data on the prevalence of CU in Korea. In light of limitations on the use of claims data, including no specific disease code for CU and a possible discordance between drug claims and the presence of urticaria symptoms, further investigations are necessary to describe the exact epidemiologic profile of CU patients.
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影响因子：
14.2
作者：
Bernstein, Jonathan A.;Lang, David M.;Wallace, Dana
通讯作者：
Wallace, Dana
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3.8
作者：
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12.4
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10.3
作者：
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通讯作者：
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影响因子：
5.1
作者：
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通讯作者：
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