The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.
The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.
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常见的粘膜免疫系统：从基本原理到与女性生殖道相关的肠道疫苗。
DOI：
10.1071/rd9940369
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Kiyono,H
中科院分区：
文献类型：
--
作者：
McGhee,JR;Xu-Amano,J;Miller,CJ;Jackson,RJ;Fujihashi,K;Staats,HF;Kiyono,H
认识到在粘膜表面诱导免疫应答可以防止病原微生物的定殖、侵入或传播，已经刺激了大量的努力来开发引发有效粘膜免疫的疫苗。在本文中，最近的结果进行了讨论，为小鼠给予霍乱毒素作为免疫原和作为佐剂诱导体液和胃肠道粘膜免疫反应。霍乱毒素单独口服或与破伤风类毒素蛋白疫苗联合口服可在派伊尔集合淋巴结和脾脏中诱导强烈的2型辅助性T细胞（TH2）应答。血清IgG和分泌型伊加抗体特异性霍乱毒素或共同管理的蛋白破伤风类毒素诱导。然而，当胃肠外给药时，没有明显的粘膜抗体应答，并且在脾脏中观察到混合的TH1和TH2型CD4+ T细胞应答。各种载体被用于不仅诱导粘膜免疫应答，而且将应答导向TH1型应答，认为其促进强细胞介导的免疫应答，或导向TH2型应答以获得最大的B细胞抗体应答。操纵TH细胞应答的能力可能为疫苗的设计提供更合理的方法。虽然女性生殖道的淋巴组织不同于肠道的淋巴组织，但许多策略和不断发展的原则可能直接适用于预防性传播疾病的疫苗的开发。
The realization that induction of immune responses at mucosal surfaces may prevent colonization, invasion or dissemination of pathogenic microorganisms has spurred intensive efforts to develop vaccines which elicit effective mucosal immunity. In this paper, recent results are discussed for mice given cholera toxin as both an immunogen and as an adjuvant for inducing both humoral and gastrointestinal mucosal immune responses. Oral administration of cholera toxin alone or with a co-administered protein vaccine tetanus toxoid induces a strong T helper type 2 (TH2) cell response in both Peyer's patches and spleen. Both serum IgG and secretory IgA antibodies specific for cholera toxin or for the co-administered protein tetanus toxoid were induced. When administered parentally, however, no mucosal antibody responses were evident and a mixed TH1- and TH2-type CD4+ T cell response was noted in the spleen. Various vectors are being employed in an effort not only to induce mucosal immune responses but also to direct the response to a TH1-type response, thought to promote strong cell-mediated immune responses, or to a TH2-type response for maximum B cell antibody responses. The ability to manipulate the TH cell responses may provide a more rational approach for the design of vaccines. Although lymphoid tissues of the female reproductive tract differ from that of the gut, many of the strategies and evolving principles may be directly applicable to the development of vaccines designed to prevent sexually transmitted diseases.
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影响因子：
4.4
作者：
T. Mosmann;H. Cherwinski;M. Bond;M. Giedlin;R. Coffman
通讯作者：
T. Mosmann;H. Cherwinski;M. Bond;M. Giedlin;R. Coffman
性类固醇激素对大鼠子宫分泌物中IgA和IgG的调节
影响因子：
64.8
作者：
C. Wira;C. Sandoe
通讯作者：
C. Sandoe
小鼠肠道相关组织中 Th1 和 Th2 细胞的分析。
DOI：
--
发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Taguchi,T;McGhee,JR;Coffman,RL;Beagley,KW;Eldridge,JH;Takatsu,K;Kiyono,H
通讯作者：
Kiyono,H
由派尔氏斑 T 细胞产生的白细胞介素 5 和白细胞介素 4 选择性增强免疫球蛋白 A 的表达。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Murray,PD;McKenzie,DT;Swain,SL;Kagnoff,MF
通讯作者：
Kagnoff,MF
有证据表明皮肤抗原呈递细胞在接触致敏过程中迁移至区域淋巴结。
DOI：
--
发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kripke,ML;Munn,CG;Jeevan,A;Tang,JM;Bucana,C
通讯作者：
Bucana,C