Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena.
Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena.
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DOI：
10.3389/fgene.2014.00286
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发表时间：
2014
影响因子：
3.7
通讯作者：
Yamamoto T
中科院分区：
文献类型：
--
作者：
Shirai YT;Suzuki T;Morita M;Takahashi A;Yamamoto T
TATA-less（NOT）复合物上的碳分解代谢物阻遏4（CCR 4）-阴性作为真核生物的主要去腺苷酸酶之一。虽然它最初是在酵母中鉴定和表征的，但最近的研究表明，CCR 4-NOT复合物在哺乳动物中也发挥着重要的功能，包括人类。然而，哺乳动物和酵母之间的CCR 4-NOT复合物的组成和功能存在一些差异。值得注意的是，CCR 4-NOT复合物的每个亚基都具有独特的多功能作用，并负责各种生理现象。CCR 4-NOT复合物的这种异质性和多功能性使得对这种复合物的全面理解变得困难。在这里，我们描述了哺乳动物CCR 4-NOT复合物的每个亚基的功能，并讨论了它调节哺乳动物体内稳态的分子机制。此外，还将讨论CCR 4-NOT复合物的破坏与各种疾病之间的可能联系。最后，我们建议，分析小鼠与每个CCR 4-NOT亚基敲除是一个有效的策略，以阐明其复杂的功能和网络在哺乳动物中。
The carbon catabolite repression 4 (CCR4)–negative on TATA-less (NOT) complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4–NOT complex also exerts important functions in mammals, -including humans. However, there are some differences in the composition and functions of the CCR4–NOT complex between mammals and yeast. It is noteworthy that each subunit of the CCR4–NOT complex has unique, multifunctional roles and is responsible for various physiological phenomena. This heterogeneity and versatility of the CCR4–NOT complex makes an overall understanding of this complex difficult. Here, we describe the functions of each subunit of the mammalian CCR4–NOT complex and discuss the molecular mechanisms by which it regulates homeostasis in mammals. Furthermore, a possible link between the disruption of the CCR4–NOT complex and various diseases will be discussed. Finally, we propose that the analysis of mice with each CCR4–NOT subunit knocked out is an effective strategy for clarifying its complicated functions and networks in mammals.
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影响因子：
3.7
作者：
Doidge R;Mittal S;Aslam A;Winkler GS
通讯作者：
Winkler GS
影响因子：
3.3
作者：
Aslam, Akhmed;Mittal, Saloni;Winkler, G. Sebastiaan
通讯作者：
Winkler, G. Sebastiaan
影响因子：
3.9
作者：
Doidge, Rachel;Mittal, Saloni;Winkler, G. Sebastiaan
通讯作者：
Winkler, G. Sebastiaan
影响因子：
30.8
作者：
De Keersmaecker K;Atak ZK;Li N;Vicente C;Patchett S;Girardi T;Gianfelici V;Geerdens E;Clappier E;Porcu M;Lahortiga I;Lucà R;Yan J;Hulselmans G;Vranckx H;Vandepoel R;Sweron B;Jacobs K;Mentens N;Wlodarska I;Cauwelier B;Cloos J;Soulier J;Uyttebroeck A;Bagni C;Hassan BA;Vandenberghe P;Johnson AW;Aerts S;Cools J
通讯作者：
Cools J
影响因子：
5.6
作者：
Chen, JJ;Rappsilber, J;Denis, CL
通讯作者：
Denis, CL