The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker.
The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker.
复制标题
水通道蛋白9在健康中的多方面作用及其作为临床生物标志物的潜力。
DOI：
10.3390/biom12070897
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发表时间：
2022-06-27
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
水通道蛋白（AQP）是水、能量和氧化还原稳态所必需的跨膜通道，已证实参与多种病理生理学状况，如水肿、青光眼、肾源性尿崩症、氧化应激、败血症、癌症和代谢功能障碍。存在于人类的13种AQP广泛分布于身体的各个区域，绘制了与细胞天然功能密切相关的细胞谱系特异性表达模式。令人信服的证据表明，AQPs是具有巨大潜力的生物标志物和治疗干预的目标蛋白质。水通道蛋白-9（AQP 9）在肝脏中表达最多，由于其水甘油孔蛋白和过氧化物孔蛋白活性，促进甘油和过氧化氢（H2 O2）跨膜扩散，从而影响一般代谢和氧化还原平衡。AQP 9也在其他组织中表达，并且它们的改变的表达在几种人类疾病中被描述，如肝损伤、炎症、癌症、不育和免疫疾病。本文综述了AQP 9在疾病中的作用，并强调了其作为临床诊断和预后的新生物标志物的潜力。
Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis, cancer, and metabolic dysfunctions. The 13 AQPs present in humans are widely distributed in all body districts, drawing cell lineage-specific expression patterns closely related to cell native functions. Compelling evidence indicates that AQPs are proteins with great potential as biomarkers and targets for therapeutic intervention. Aquaporin-9 (AQP9) is the most expressed in the liver, with implications in general metabolic and redox balance due to its aquaglyceroporin and peroxiporin activities, facilitating glycerol and hydrogen peroxide (H2O2) diffusion across membranes. AQP9 is also expressed in other tissues, and their altered expression is described in several human diseases, such as liver injury, inflammation, cancer, infertility, and immune disorders. The present review compiles the current knowledge of AQP9 implication in diseases and highlights its potential as a new biomarker for diagnosis and prognosis in clinical medicine.
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影响因子：
4.8
作者：
Bienert, Gerd P.;Moller, Anders L. B.;Jahn, Thomas P.
通讯作者：
Jahn, Thomas P.
影响因子：
11.4
作者：
Bestetti, Stefano;Galli, Mauro;Medrano-Fernandez, Iria
通讯作者：
Medrano-Fernandez, Iria
影响因子：
4.8
作者：
Amiry-Moghaddam, M;Lindland, H;Ottersen, OP
通讯作者：
Ottersen, OP
DOI：
10.1007/978-94-024-1057-0_15
发表时间：
2017-01-01
期刊：
AQUAPORINS
影响因子：
--
作者：
da Silva, Ines Vieira;Soveral, Graca
通讯作者：
Soveral, Graca
影响因子：
13.5
作者：
Carreras, FI;Gradilone, SA;Marinelli, RA
通讯作者：
Marinelli, RA