The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate?
The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate?
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DOI：
10.1002/hbm.20732
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发表时间：
2009-10
影响因子：
4.8
通讯作者：
Laurienti, Paul J.
中科院分区：
文献类型：
--
作者：
Addicott, Merideth A.;Yang, Lucie L.;Peiffer, Ann M.;Burnett, Luke R.;Burdette, Jonathan H.;Chen, Michael Y.;Hayasaka, Satoru;Kraft, Robert A.;Maldjian, Joseph A.;Laurienti, Paul J.
咖啡因是一种常用的神经兴奋剂，也通过拮抗腺苷受体产生脑血管收缩。长期使用咖啡因导致血管腺苷受体系统的适应性变化，可能是为了补偿咖啡因的血管收缩作用。我们研究了咖啡因对脑血流量（CBF）的影响，慢性咖啡因使用水平的增加。低（平均值= 45毫克/天），中度（平均值= 405毫克/天），高（平均值= 950毫克/天）咖啡因用户进行定量灌注磁共振成像在四个不同的场合：两次在咖啡因戒断状态（戒断状态）和两次在含咖啡因的状态后，他们的正常咖啡因使用（自然状态）。在每个州有两种药物条件：参与者接受咖啡因（250毫克）或安慰剂。采用重复测量方差分析，以咖啡因使用作为被试间因素，对脑灰质CBF进行了测试，并对CBF和咖啡因使用之间进行了相关分析。在两种咖啡因状态下，咖啡因使CBF平均降低27%。在弃权的安慰剂条件下，中度和高度用户有类似的更大的CBF比低用户，但在本地安慰剂条件下，高用户有一个趋势，CBF比低和中度用户。我们的研究结果表明，脑血管腺苷系统的能力有限，以弥补大量的日常咖啡因的使用。
Caffeine is a commonly used neurostimulant that also produces cerebral vasoconstriction by antagonizing adenosine receptors. Chronic caffeine use results in an adaptation of the vascular adenosine receptor system presumably to compensate for the vasoconstrictive effects of caffeine. We investigated the effects of caffeine on cerebral blood flow (CBF) in increasing levels of chronic caffeine use. Low (mean = 45 mg/day), moderate (mean = 405 mg/day), and high (mean = 950 mg/day) caffeine users underwent quantitative perfusion magnetic resonance imaging on four separate occasions: twice in a caffeine abstinent state (abstained state) and twice in a caffeinated state following their normal caffeine use (native state). In each state there were two drug conditions: participants received either caffeine (250 mg) or placebo. Gray matter CBF was tested with repeated-measures analysis of variance using caffeine use as a between-subjects factor, and correlational analyses were conducted between CBF and caffeine use. Caffeine reduced CBF by an average of 27% across both caffeine states. In the abstained placebo condition, moderate and high users had similarly greater CBF than low users; but in the native placebo condition, the high users had a trend towards less CBF than the low and moderate users. Our results suggest a limited ability of the cerebrovascular adenosine system to compensate for high amounts of daily caffeine use.
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影响因子：
4.9
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