A novel, benchtop model for quantitative analysis of resistance in ventricular catheters.
A novel, benchtop model for quantitative analysis of resistance in ventricular catheters.
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DOI：
10.1371/journal.pone.0294811
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
导管阻塞的机制仍然知之甚少，但文献表明流体流动的阻力起着重要作用。我们开发并评估了一种重力驱动装置，用于测量通过心室导管的流量。我们使用该装置对脑积水治疗中未使用的脑室导管的阻力进行定量分析；我们还对导管生物库中失败的脑积水导管进行了定量评估。三个制造公司的导管被插入台式模型中，该模型使用传感器记录时间、流速和压力数据。评估了六种设计模型中导管的相对阻力。进行实验以评估当导管孔逐渐闭合时导管相对阻力的变化。还测量了从我们的导管生物储存库中移出的导管的相对阻力。实验结果显示，不同型号导管刚从包装中取出后的相对电阻存在显着差异（P<0.05）。在人工堵塞孔的导管实验中观察到阻力增加的非线性趋势。对五个单独台式模型的数据进行了比较，发现模型之间测量数据的差异可以忽略不计。在外植导管中观察到相对阻力显着增加（P < 0.05）。当前的研究试图提出一种新颖的体外模型，并用它来检查导管模型之间相对阻力差异的数据。通过这些实验，我们可以快速关联临床患者队列，以确定管腔分流阻塞的机制。
The mechanisms of catheter obstruction are still poorly understood, but the literature suggests that resistance to fluid flow plays a significant role. We developed and assessed a gravity-driven device that measures flow through ventricular catheters. We used this device to quantitatively analyze the resistances of unused ventricular catheters used in the treatment of hydrocephalus; failed hydrocephalus catheters from our catheter biorepository were also evaluated quantitatively. Catheters of three manufacturing companies were inserted into the benchtop model, which records time, flow rate, and pressure data using sensors. The relative resistances of catheters across six design models were evaluated. Experiments were performed to evaluate changes in the relative resistance of a catheter when the catheter’s holes were progressively closed. The relative resistance of explanted catheters from our catheter biorepository was also measured. Experimental results showed significant differences (P<0.05) between the relative resistances of different catheter models just after being removed from their packaging. A non-linear trend of increasing resistance was observed in experiments on catheters with artificially obstructed holes. Data from five individual benchtop models were compared, and the differences in measured data between the models were found to be negligible. A significant increase (P < 0.05) in relative resistance was observed in explanted catheters. The current study sought to propose a novel in-vitro model and use it to examine data on differences in relative resistance among catheter models. From these experiments, we can rapidly correlate clinical patient cohorts to identify mechanisms of luminal shunt obstruction.
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