Partial Obstruction of Ventricular Catheters Affects Performance in a New Catheter Obstruction Model of Hydrocephalus.
Partial Obstruction of Ventricular Catheters Affects Performance in a New Catheter Obstruction Model of Hydrocephalus.
复制标题
DOI：
10.3390/children9101453
复制
发表时间：
2022-09-23
期刊：
影响因子：
2.4
通讯作者：
Muhonen, Michael
中科院分区：
文献类型：
--
作者：
Lee, Seunghyun;Vinzani, Michael;Romero, Bianca;Chan, Alvin Y.;Castaneyra-Ruiz, Leandro;Muhonen, Michael
目的：脑室分流失败的主要原因之一是近端导管堵塞。我们描述了一种新的脑室脑脊液（CSF）流复制系统，评估不同程度的导管闭塞的压力和流量响应。方法：在部分和完全闭塞条件下评估脑室导管性能。将导管放入三维打印的体模心室复制系统中。以1 mL/min的恒定速率通过脑室系统泵入人工CSF，以模拟CSF流动，导管近端位于体模脑室中。压力传感器和流速传感器用于测量体模内压力、流出压力和CSF流速。将导管插入硅胶管中，并以相同方式测量压力，以与体模进行比较。结果：当脑室导管流出部分闭塞时，脑室体模中测得的压力没有变化。然而，当流出导管100%闭塞时，脑室内体模压力显著增加。通过导管的流量在导管的任何程度的部分闭塞的情况下均未显示出显著的速率差异。在部分闭塞导管的远端，与未闭塞导管相比，压力较小。部分闭塞导管中的这种压力差异与导管孔闭塞的百分比相关。结论：我们的模型模拟了部分和完全阻塞的脑室导管中CSF流动的生理动力学。我们发现导管的部分闭塞对CSF流速没有影响，但确实降低了导管的流出压力。
Objective: One of the major causes of cerebral ventricular shunt failure is proximal catheter occlusion. We describe a novel ventricular cerebrospinal fluid (CSF) flow replicating system that assesses pressure and flow responses to varying degrees of catheter occlusion. Methods: Ventricular catheter performance was assessed during conditions of partial and complete occlusion. The catheters were placed into a three-dimensionally-printed phantom ventricular replicating system. Artificial CSF was pumped through the ventricular system at a constant rate of 1 mL/min to mimic CSF flow, with the proximal end of the catheter in the phantom ventricle. Pressure transducer and flow rate sensors were used to measure intra-phantom pressure, outflow pressure, and CSF flow rates. The catheters were also inserted into silicone tubing and pressure was measured in the same manner for comparison with the phantom. Results: Pressure measured in the ventricle phantom did not change when the outflow of the ventricular catheter was partially occluded. However, the intraventricular phantom pressure significantly increased when the outflow catheter was 100% occluded. The flow through the catheter showed no significant difference in rate with any degree of partial occlusion of the catheter. At the distal end of the partially occluded catheters, there was less pressure compared with the nonoccluded catheters. This difference in pressure in partially occluded catheters correlated with the percentage of catheter hole occlusion. Conclusions: Our model mimics the physiological dynamics of the CSF flow in partially and completely obstructed ventricular catheters. We found that partial occlusion of the catheter had no effect on the CSF flow rate, but did reduce outflow pressure from the catheter.
登录
查看更多内容
影响因子：
0.7
作者：
Ginsberg, HJ;Sum, A;Cobbold, RSC
通讯作者：
Cobbold, RSC
影响因子：
2
作者：
Devathasan, Dillon;Bentley, R. Timothy;Lee, Hyowon
通讯作者：
Lee, Hyowon
影响因子：
1.9
作者：
Hanak, Brian W.;Ross, Emily F.;Shain, William
通讯作者：
Shain, William
DOI：
10.1002/jbm.b.33915
发表时间：
2018-04-01
影响因子：
3.4
作者：
Hanak, Brian W.;Hsieh, Chia-Yun;Shain, William
通讯作者：
Shain, William
影响因子：
1.9
作者：
Kulkarni, Abhaya V.;Riva-Cambrin, Jay;Whitehead, William E.
通讯作者：
Whitehead, William E.