Dental Implant Nano-Engineering: Advances, Limitations and Future Directions.
Dental Implant Nano-Engineering: Advances, Limitations and Future Directions.
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牙种植体纳米工程：进展、局限性和未来方向
DOI：
10.3390/nano11102489
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发表时间：
2021-09-24
期刊：
影响因子：
--
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Zhang Y;Gulati K;Li Z;Di P;Liu Y
钛（Ti）及其合金具有良好的生物相容性、机械性能和耐腐蚀性，这使其成为牙种植体的理想材料选择。然而，由于种植体相关感染和骨整合不足，钛基牙种植体的长期成功可能受到挑战。随着纳米技术的发展，纳米级改性和纳米材料的应用已成为牙种植体研究的重点关注领域。表面改性和各种涂层的使用，以及抗生素或蛋白质控释的发展，提高了牙种植体的骨整合和软组织整合，以及它们的抗菌和免疫调节功能。本综述介绍了用于钛基牙种植体的形貌改性和表面涂层的近期纳米工程技术和材料。对这些进展进行了讨论和详细阐述，包括对其生物相容性、毒性、抗菌活性和体内性能的证据评估。对这些纳米工程尝试的比较表明，在其临床转化方面仍存在必须解决的研究空白。例如，定制三维打印技术以及刺激响应、多功能和时间可编程的种植体表面在推动该领域发展方面具有很大的潜力。此外，需要在生理条件下进行长期体内研究，以确保纳米材料改性牙种植体的临床应用。
Titanium (Ti) and its alloys offer favorable biocompatibility, mechanical properties and corrosion resistance, which makes them an ideal material choice for dental implants. However, the long-term success of Ti-based dental implants may be challenged due to implant-related infections and inadequate osseointegration. With the development of nanotechnology, nanoscale modifications and the application of nanomaterials have become key areas of focus for research on dental implants. Surface modifications and the use of various coatings, as well as the development of the controlled release of antibiotics or proteins, have improved the osseointegration and soft-tissue integration of dental implants, as well as their antibacterial and immunomodulatory functions. This review introduces recent nano-engineering technologies and materials used in topographical modifications and surface coatings of Ti-based dental implants. These advances are discussed and detailed, including an evaluation of the evidence of their biocompatibility, toxicity, antimicrobial activities and in-vivo performances. The comparison between these attempts at nano-engineering reveals that there are still research gaps that must be addressed towards their clinical translation. For instance, customized three-dimensional printing technology and stimuli-responsive, multi-functional and time-programmable implant surfaces holds great promise to advance this field. Furthermore, long-term in vivo studies under physiological conditions are required to ensure the clinical application of nanomaterial-modified dental implants.
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影响因子：
3.9
作者：
Bertoni, E;Bigi, A;Roveri, N
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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