Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation.
Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation.
复制标题
大鼠超声波发声的生物学功能，唤醒机制和呼叫启动。
DOI：
10.3390/brainsci11050605
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发表时间：
2021-05-09
期刊：
影响因子：
3.3
通讯作者：
Brudzynski SM
中科院分区：
文献类型：
--
作者：
Brudzynski SM
本文综述了所有的报告和怀疑功能的超声发声在婴儿和成年大鼠。综述得出的结论是，所有类型的超声波发声subserving所有功能的情绪唤起的脑干网状核心的活动发起的声音表达。情绪唤醒在本质上是二分的，并且由两个功能相反的上行网状系统启动，这两个上行网状系统与认知网状激活系统分离。中脑边缘胆碱能系统启动焦虑的厌恶状态，伴随发射22 kHz的呼叫，而中脑边缘多巴胺能系统启动快感的食欲状态，伴随发射50 kHz的发声。这两个相互排斥的唤醒系统使动物准备两种不同的行为结果。宽带婴儿隔离呼叫的结构良好的成人类型的发声的过渡进行了解释，并强调了成年大鼠声乐通信的社会重要性。22 kHz和50 kHz发声分别与厌恶和食欲状态的关联被用于生理学、心理学、神经学、神经精神学和神经发育研究的许多定量测量的临床前模型中。本综述应有助于理解和解释这些模型在生物医学研究。
This review summarizes all reported and suspected functions of ultrasonic vocalizations in infant and adult rats. The review leads to the conclusion that all types of ultrasonic vocalizations subserving all functions are vocal expressions of emotional arousal initiated by the activity of the reticular core of the brainstem. The emotional arousal is dichotomic in nature and is initiated by two opposite-in-function ascending reticular systems that are separate from the cognitive reticular activating system. The mesolimbic cholinergic system initiates the aversive state of anxiety with concomitant emission of 22 kHz calls, while the mesolimbic dopaminergic system initiates the appetitive state of hedonia with concomitant emission of 50 kHz vocalizations. These two mutually exclusive arousal systems prepare the animal for two different behavioral outcomes. The transition from broadband infant isolation calls to the well-structured adult types of vocalizations is explained, and the social importance of adult rat vocal communication is emphasized. The association of 22 kHz and 50 kHz vocalizations with aversive and appetitive states, respectively, was utilized in numerous quantitatively measured preclinical models of physiological, psychological, neurological, neuropsychiatric, and neurodevelopmental investigations. The present review should help in understanding and the interpretation of these models in biomedical research.
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影响因子：
8.2
作者：
Apfelbach, R;Blanchard, CD;McGregor, IS
通讯作者：
McGregor, IS
DOI：
10.1037/h0076435
发表时间：
1975-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BARFIELD, RJ;GEYER, LA
通讯作者：
GEYER, LA
DOI：
10.1037/h0077458
发表时间：
1978-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ALBERTS, JR
通讯作者：
ALBERTS, JR
影响因子：
56.9
作者：
BARFIELD, RJ;GEYER, LA
通讯作者：
GEYER, LA
影响因子：
8.2
作者：
Antoniou, K;Kafetzopoulos, E;Marselos, M
通讯作者：
Marselos, M