Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using (13)C-Labeling and QTOF-MS.
Identification of an Epoxide Metabolite of Lycopene in Human Plasma Using (13)C-Labeling and QTOF-MS.
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DOI：
10.3390/metabo8010024
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发表时间：
2018-03-20
期刊：
影响因子：
4.1
通讯作者：
Clinton SK
中科院分区：
文献类型：
--
作者：
Cichon MJ;Moran NE;Riedl KM;Schwartz SJ;Clinton SK
类胡萝卜素番茄红素是番茄的一种生物活性成分，被认为可以降低患前列腺癌等多种慢性疾病的风险。番茄红素的代谢才刚刚开始被理解，一些研究表明，番茄红素的代谢产物可能是与母体化合物相关的生物活性的部分原因。这些化合物在体内的检测和表征是了解番茄红素生物活性的重要一步。番茄红素的代谢可能涉及化学氧化和酶促氧化。虽然已经提出了许多番茄红素代谢物，但实际上在番茄红素摄入后在体内鉴定的很少。在这里，LC-QTOF-MS被沿着与13 C-标记一起用于研究人血浆中番茄红素的餐后氧化代谢。以前报道的醛裂解产物没有检测到，但番茄红素1，2-环氧化物被确定为一个新的候选氧化代谢产物。
The carotenoid lycopene is a bioactive component of tomatoes and is hypothesized to reduce risk of several chronic diseases, such as prostate cancer. The metabolism of lycopene is only beginning to be understood and some studies suggest that metabolites of lycopene may be partially responsible for bioactivity associated with the parent compound. The detection and characterization of these compounds in vivo is an important step in understanding lycopene bioactivity. The metabolism of lycopene likely involves both chemical and enzymatic oxidation. While numerous lycopene metabolites have been proposed, few have actually been identified in vivo following lycopene intake. Here, LC-QTOF-MS was used along with 13C-labeling to investigate the post-prandial oxidative metabolism of lycopene in human plasma. Previously reported aldehyde cleavage products were not detected, but a lycopene 1,2-epoxide was identified as a new candidate oxidative metabolite.
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
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DOI：
10.1024/0300-9831.69.5.303
发表时间：
1999-09-01
影响因子：
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作者：
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影响因子：
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