Targeting iron metabolism in cancer therapy.
Targeting iron metabolism in cancer therapy.
复制标题
靶向癌症治疗中的铁代谢。
作者：
Morales M;Xue X
铁是许多细胞功能的重要组成部分，包括DNA复制和修复，它对细胞活力至关重要。作为人体必需的元素，铁对维持人体健康至关重要。然而，过量的铁可能是高毒性的，导致氧化DNA损伤。许多研究已经观察到铁和癌症之间的显着关联，这种关联似乎不仅仅是巧合。癌症的主要特征是过度增殖，这使得它们比正常细胞更依赖铁。癌症治疗方法正变得与疾病本身一样多样化。靶向癌细胞中的铁代谢是一个新兴的，强大的治疗领域。这是一项在具体目标和实现这些目标的各种方式方面高度多样化的战略。这篇综述将讨论铁代谢在癌症中的重要性，并强调它作为明天的医学正在探索的方式。
Iron is a critical component of many cellular functions including DNA replication and repair, and it is essential for cell vitality. As an essential element, iron is critical for maintaining human health. However, excess iron can be highly toxic, resulting in oxidative DNA damage. Many studies have observed significant associations between iron and cancer, and the association appears to be more than just coincidental. The chief characteristic of cancers, hyper-proliferation, makes them even more dependent on iron than normal cells. Cancer therapeutics are becoming as diverse as the disease itself. Targeting iron metabolism in cancer cells is an emerging, formidable field of therapeutics. It is a strategy that is highly diverse with regard to specific targets and the various ways to reach them. This review will discuss the importance of iron metabolism in cancer and highlight the ways in which it is being explored as the medicine of tomorrow.
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影响因子：
3
作者：
Daniels, Tracy R.;Bernabeu, Ezequiel;Rodriguez, Jose A.;Patel, Shabnum;Kozman, Maggie;Chiappetta, Diego A.;Holler, Eggehard;Ljubimova, Julia Y.;Helguera, Gustavo;Penichet, Manuel L.
通讯作者：
Penichet, Manuel L.
影响因子：
13.6
作者：
Chung, Eunna;Choi, Youngsil;Jo, Daewoong
通讯作者：
Jo, Daewoong
影响因子：
2.6
作者：
Benadiba, Joy;Rosilio, Celia;Peyron, Jean-Francois
通讯作者：
Peyron, Jean-Francois
DOI：
10.1111/hdi.12542
发表时间：
2017-06
期刊：
Hemodialysis international. International Symposium on Home Hemodialysis
影响因子：
--
作者：
Dev S;Babitt JL
通讯作者：
Babitt JL
影响因子：
5.7
作者：
Campisi, Agata;Bonfanti, Roberta;Parenti, Rosalba
通讯作者：
Parenti, Rosalba