Overview of iron metabolism in health and disease.

Overview of iron metabolism in health and disease.
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DOI:
10.1111/hdi.12542
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发表时间:
2017-06
期刊:
Hemodialysis international. International Symposium on Home Hemodialysis
影响因子:
--
通讯作者:
Babitt JL
Babitt JL
中科院分区:
其他
文献类型:
--
作者:
Dev S;Babitt JL

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铁是许多基本生物过程的必需元素,但过量的铁是有毒的。系统性铁平衡异常在慢性肾病(CKD)患者中很常见,铁治疗是许多患者贫血治疗的主要手段。本文综述了铁在生物学中的重要作用,对全身和细胞铁稳态的调节,铁稳态失衡如何导致疾病,以及对慢性肾病患者的影响。
Iron is an essential element for numerous fundamental biologic processes, but excess iron is toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney disease (CKD) and iron administration is a mainstay of anemia management in many patients. This review provides an overview of the essential role of iron in biology, the regulation of systemic and cellular iron homeostasis, how imbalances in iron homeostasis contribute to disease, and the implications for CKD patients.
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