Advantage of PET/CT in Target Delineation of MRI-negative Cervical Lymph Nodes In Intensity-Modulated Radiation Therapy Planning for Nasopharyngeal Carcinoma.
Advantage of PET/CT in Target Delineation of MRI-negative Cervical Lymph Nodes In Intensity-Modulated Radiation Therapy Planning for Nasopharyngeal Carcinoma.
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DOI：
10.7150/jca.21582
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发表时间：
2017
影响因子：
3.9
通讯作者：
Deng X
中科院分区：
文献类型：
--
作者：
Shen G;Xiao W;Han F;Fan W;Lin XP;Lu L;Zheng L;Yue N;Haffty B;Zhao C;Deng X
简介：在鼻咽癌 (NPC) 调强放射治疗 (IMRT) 计划中，磁共振成像 (MRI) 扫描呈阴性的颈部淋巴结 (CLN) 可能难以定位。本研究的目的是评估 18F-氟脱氧葡萄糖正电子发射断层扫描联合计算机断层扫描 (18F-FDG PET/CT) 在区分 MRI 阴性 CLN 方面的优势，以及 18F-FDG PET/CT 在鼻咽癌 IMRT 规划中的诊断、靶区勾画和剂量处方的效果。方法：35 例 37 个 MRI 阴性 CLN 的鼻咽癌患者在治疗前接受 18F-FDG PET/CT 成像。超声引导下的细针抽吸细胞学检查 (USgFNAC) 用于检查 CLN 的病理学。比较 18F-FDG PET/CT 与细胞病理学结果，计算 18F-FDG PET/CT 的诊断准确性。细胞病理学证实的 CLN 被描绘并处理为淋巴结的总肿瘤体积（表示为 GTVnd）。结果：37 个 MRI 阴性的 CLN 中有 19 个 18F-FDG PET/CT 呈阳性，16 个 CLN 经 USgFNAC 证实有转移。剩余的18个 18F-FDG PET/CT阴性淋巴结中，1个被确认为转移。 18F-FDG PET/CT 诊断准确率、敏感性和特异性分别为 89.2%、94.1% 和 85.0%。阳性和阴性预测值分别为84.2%和94.4%。中位随访时间为 48.3 个月，经 USgFNAC 确诊并接受 GTVnd 治疗的 18F-FDG PET/CT 阳性 CLN 中未观察到复发。结论:~(18)F-FDG PET/CT对于区分MRI阴性CLN具有较高的准确性、敏感性和特异性。在 NPC 的 IMRT 计划中，18F-FDG PET/CT 阳性 CLN 可以合理地归类为高风险临床肿瘤体积。
Introduction: In intensity-modulated radiation therapy (IMRT) planning for nasopharyngeal carcinoma (NPC), cervical lymph nodes (CLNs) that appear negative on magnetic resonance imaging (MRI) scans can be difficult to target. The purpose of this study was to assess the advantage of 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG PET/CT) for distinguishing MRI-negative CLNs and the effect of 18F-FDG PET/CT on diagnosis, target delineation, and dose prescription in IMRT planning for NPC. Methods: Thirty-five NPC patients with 37 MRI-negative CLNs underwent 18F-FDG PET/CT imaging before treatment. Ultrasonography-guided fine-needle aspiration cytology (USgFNAC) was performed to examine the pathology of CLNs. The 18F-FDG PET/CT and cytopathological results were compared, and the diagnostic accuracy of 18F-FDG PET/CT was calculated. The cytopathologically confirmed CLNs were delineated and treated as the gross tumor volume of lymph nodes (denoted as GTVnd). Results: Nineteen of the 37 MRI-negative CLNs were positive on 18F-FDG PET/CT, and metastasis was confirmed by USgFNAC in 16 CLNs. Of the remaining 18 18F-FDG PET/CT-negative lymph nodes, metastasis was confirmed in one. The diagnostic accuracy, sensitivity, and specificity of 18F-FDG PET/CT were 89.2%, 94.1%, and 85.0%, respectively. The positive and negative predictive values were 84.2% and 94.4%, respectively. With a median follow-up of 48.3 months, no relapse was observed among the 18F-FDG PET/CT-positive CLNs with metastasis confirmed by USgFNAC and treated as GTVnd. Conclusion: 18F-FDG PET/CT had high accuracy, sensitivity, and specificity for distinguishing MRI-negative CLNs. 18F-FDG PET/CT-positive CLNs could reasonably be categorized as high-risk clinical tumor volume in IMRT planning for NPC.
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影响因子：
1.9
作者：
Sigg, MB;Steinert, H;Eyrich, GK
通讯作者：
Eyrich, GK
影响因子：
3.9
作者：
Xue, Fen;Hu, Chaosu;He, Xiayun
通讯作者：
He, Xiayun
影响因子：
2.6
作者：
DON, DM;ANZAI, Y;CALCATERRA, TC
通讯作者：
CALCATERRA, TC
DOI：
10.1186/s40644-016-0096-y
发表时间：
2016-11-03
期刊：
Cancer imaging : the official publication of the International Cancer Imaging Society
影响因子：
--
作者：
Hempel JM;Kloeckner R;Krick S;Pinto Dos Santos D;Schadmand-Fischer S;Boeßert P;Bisdas S;Weber MM;Fottner C;Musholt TJ;Schreckenberger M;Miederer M
通讯作者：
Miederer M
影响因子：
5.7
作者：
Sun, Xueming;Su, Shengfa;Lu, Taixiang
通讯作者：
Lu, Taixiang