Ethnobotany as a pharmacological research tool and recent developments in CNS-active natural products from ethnobotanical sources.
Ethnobotany as a pharmacological research tool and recent developments in CNS-active natural products from ethnobotanical sources.
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DOI：
10.1016/j.pharmthera.2009.04.002
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发表时间：
2009-08
影响因子：
13.5
通讯作者：
Savo, Valentina
中科院分区：
文献类型：
--
作者：
McClatchey, Will C.;Mahady, Gail B.;Bennett, Bradley C.;Shiels, Laura;Savo, Valentina
根据民族植物学对天然产物研究的多学科贡献，对民族植物学进行了回顾，以开发药物和药理工具。审查的一些问题涉及医疗保健和药用植物的伦理和文化视角。虽然这些通常不是药理学讨论的一部分，但文化问题可能会给现场和实验室的研究人员带来挑战和洞察力。植物进化问题也被考虑，因为它们与植物化学的发展有关，并通过民族植物学方法获得这一点。讨论包括介绍最近在野外、实验室和/或临床上检查的一系列具有中枢神经系统活性的药用植物。这些植物中的每一种都用来说明民族植物学在药理学研究中的有价值的作用的一个或多个方面。最后，我们考虑了野外民族植物学家和药理学家之间互惠互利的未来合作。
The science of ethnobotany is reviewed in light of its multidisciplinary contributions to natural product research for the development of pharmaceuticals and pharmacological tools. Some of the issues reviewed involve ethical and cultural perspectives of healthcare and medicinal plants. While these are not usually part of the discussion of pharmacology, cultural concerns potentially provide both challenges and insight for field and laboratory researchers. Plant evolutionary issues are also considered as they relate to development of plant chemistry and accessing this through ethnobotanical methods. The discussion includes presentation of a range of CNS-active medicinal plants that have been recently examined in the field, laboratory and/or clinic. Each of these plants is used to illustrate one or more aspects about the valuable roles of ethnobotany in pharmacological research. We conclude with consideration of mutually beneficial future collaborations between field ethnobotanists and pharmacologists.
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