Magnetic resonance imaging of glutamate.
Magnetic resonance imaging of glutamate.
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谷氨酸（Glu）在其-胺基和大量水之间表现出pH和浓度依赖的化学交换饱和转移效应（CEST），这里称为葡萄糖转移效应。葡萄糖不对称性在油田下游的散装水约为百万分之3。在大鼠大脑中动脉闭塞后，观察到与对侧相比，同侧葡萄糖水平升高约100%，这主要是由于pH值的变化。在血脑屏障破坏的大鼠脑肿瘤模型中，静脉注射Glu导致葡萄糖耐酸酯明显升高，Glu的质子磁共振波谱信号也相应增加。还获得了健康人大脑在7T时的葡萄糖水平图。这些结果证明了GluCEST在测定体内Glu浓度和pH的相对变化方面的可行性和潜力。其他脑代谢物对葡萄糖代谢激素作用的潜在贡献也进行了讨论。
Glutamate (Glu) exhibits a pH and concentration dependent chemical exchange saturation transfer effect (CEST) between its -amine group and bulk water, here termed GluCEST. GluCEST asymmetry is observed at ~3 parts per million downfield from bulk water. Following middle cerebral artery occlusion in the rat brain, an approximately 100% elevation of GluCEST in the ipsilateral side compared to the contralateral side was observed, and is predominantly due to pH changes. In a rat brain tumor model with blood brain barrier disruption, intravenous Glu injection resulted in a clear elevation of GluCEST and a comparable increase in the proton magnetic resonance spectroscopy signal of Glu. GluCEST maps from healthy human brain at 7T were also obtained. These results demonstrate the feasibility and potential of GluCEST for mapping relative changes in Glu concentration as well as pH in vivo. Potential contributions from other brain metabolites to the GluCEST effect are also discussed.
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影响因子：
3.3
作者：
McMahon, Michael T.;Gilad, Assaf A.;DeLiso, Marco A.;Berman, Stacey D. Cromer;Bulte, Jeff W. M.;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.
影响因子：
4.4
作者：
FORSEN, S;HOFFMAN, RA
通讯作者：
HOFFMAN, RA
使用化学交换饱和转移 (CEST) MRI 对 pH 进行成像：校正伴随的 RF 辐射效应以量化 CEST MRI 的化学交换率和 pH
影响因子：
3.3
作者：
Sun, Phillip Zhe;Sorensen, A. Gregory
通讯作者：
Sorensen, A. Gregory
影响因子：
3.3
作者：
Hurd, R;Sailasuta, N;Nelson, SJ
通讯作者：
Nelson, SJ
影响因子：
9.9
作者：
Chu, WJ;Hetherington, HP;Elgavish, GA
通讯作者：
Elgavish, GA