APOE E4 Carriers show prospective memory enhancement under nicotine, and evidence for specialisation within medial BA10.
APOE E4 Carriers show prospective memory enhancement under nicotine, and evidence for specialisation within medial BA10.
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DOI：
10.1038/npp.2012.230
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发表时间：
2013-03
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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有证据表明，apoEε4等位基因(它增加了患痴呆症的风险)可能与生命早期的认知优势有关。此外，尼古丁可能会选择性地使ε4携带者受益。我们采用受试者内设计，使用功能磁共振成像来探索年轻人(18-30岁)在使用尼古丁和不使用尼古丁的情况下在前瞻性记忆(PM)任务中的表现。参与者执行一项正在进行的任务，同时保留PM指令以对任务中嵌入的特定刺激做出反应。尼古丁的作用因APOE状态不同而不同。在尼古丁作用下，ε4携带者对PM提示的反应时间有所改善，但ε3携带者的反应时间没有改善。在一项与事件相关的分析中，只有在ε4携带者中，尼古丁才能增强对PM试验的纹状体外反应。早期视觉处理的这些差异可能有助于行为研究结果。ε4携带者与ε3携带者的区别在于中膜BA10的活性(先前与PM有关)。在PM试验中，ε4携带者的一个BA10区显示出更大的失活。其他BA10亚区的活性受PM反应时间的调节，表明BA10内侧的区域特异性效应。此外，只有在接受尼古丁的ε4携带者中才能看到右侧海马区的活动。这些结果表明，尼古丁的认知增强可以选择性地使载脂蛋白Eε4携带者受益，并表明PM期间不同基因型的神经活动存在差异。此外，这些结果表明，内侧BA10在PM中的作用可能涉及不同功能亚区的不同贡献。
There is evidence to suggest that the APOE ε4 allele (which confers an increased risk of developing dementia) might be associated with cognitive advantages earlier in life. Further, nicotine might selectively benefit ε4 carriers. We used fMRI to explore performance on a prospective memory (PM) task in young adults (age 18-30) with and without nicotine using a within-subjects design. Participants performed an ongoing task while retaining a PM instruction to respond to specific stimuli embedded in the task. Nicotine effects varied according to APOE status. Reaction times to the PM cue were improved under nicotine in ε4 carriers, but not in ε3 carriers. In an event-related analysis, extrastriate responses to PM trials were enhanced by nicotine only in ε4 carriers. These differences in early visual processing may contribute to the behavioural findings. Activity in medial BA10 (previously implicated in PM) differentiated ε4 from ε3 carriers. One BA10 subregion showed greater deactivation in ε4 carriers during PM trials. Activity in other BA10 subregions were modulated by PM reaction time, pointing to region-specific effects within medial BA10. In addition, activity in right hippocampal formation was only seen in ε4 carriers receiving nicotine. These results demonstrate that cognitive enhancement by nicotine can selectively benefit APOE ε4 carriers, and point to genotype-specific differences in neural activity during PM. In addition, these results show that the role of medial BA10 in PM likely involves varying contributions from functionally-specific subregions.
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DOI：
10.1016/j.jalz.2009.07.003
发表时间：
2010-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Dennis NA;Browndyke JN;Stokes J;Need A;Burke JR;Welsh-Bohmer KA;Cabeza R
通讯作者：
Cabeza R
影响因子：
13.9
作者：
Bisley JW;Goldberg ME
通讯作者：
Goldberg ME
影响因子：
5.7
作者：
Friston, KJ;Zarahn, E;Dale, AM
通讯作者：
Dale, AM
影响因子：
2.6
作者：
Burgess, Paul W.;Gonen-Yaacovi, Gil;Volle, Emmanuelle
通讯作者：
Volle, Emmanuelle
DOI：
10.1037/a0015535
发表时间：
2009-07-01
影响因子：
2.6
作者：
Gilbert, Sam J.;Gollwitzer, Peter M.;Burgess, Paul W.
通讯作者：
Burgess, Paul W.